阮 科
 | 姓 名: | 阮 科 |
| 地 址: | 安徽合肥黄山路443号科大西区生命科学学院 | |
| 邮 编: | 230027 | |
| 电 话: | 0551-63607767 | |
| 电 邮: | kruan@ustc.edu.cn | |
| 主 页: |
| 教育与科研经历 |
| 2011/01-至今 | 中国科学技术大学生命科学学院，副教授 |
| 2010/02-2010/12 | 英国Beatson研究所药物研发，副研究员 |
| 2008/05-2010/02 | 美国辉瑞公司博士后 |
| 2002/09–2008/05 | 约翰霍普金斯大学，博士 |
| 1999/09–2002/07 | 北京大学化学与分子工程学院，硕士 |
| 1995/09–1999/07 | 北京大学化学与分子工程学院，学士 |
| 目前研究方向 |
| 基于片段的药物先导化合物发现，核磁新方法的发展与应用。 |
| 代表性论文 |
| 1. | Jia Gao#, E Liang#, Rongsheng Ma, Fudong Li, Yixiang Liu, Jiuyang Liu, Ling Jiang, Conggang Li, Haiming Dai, Jihui Wu, Xuncheng Su, Wei He, Ke Ruan*, Fluorine Pseudocontact Shifts Used for Characterizing the protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange, Angew. Chem. Int. Ed., 2017, 56(42): 12982-12986 |
| 2. | Difei Xu#, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang*, Ke Ruan*, Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy, J. Phys. Chem. Lett., 2018 9(14): 4020-4028 |
| 3. | Difei Xu#, Bin Li#, Jia Gao#, Zhijun Liu, Xiaogang Niu, Gilbert Nshogoza, Jiahai Zhang, Jihui Wu, Xun-Cheng Su, Wei He, Rongsheng Ma*, Daiwen Yang*, Ke Ruan*, Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange, J. Phys. Chem. Lett., 2018, 9(12): 3361-3367 |
| 4. | Jiuyang Liu#, Shuya Zhang#, Mingqing Liu, Yaqian Liu, Gilbert Nshogoza, Jia Gao, Rongsheng Ma, Yang Yang, Jihui Wu, Jiahai Zhang*, Fudong Li*, Ke Ruan*, Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit, FEBS J. 2018, 285(11): 2091-2103 |
| 5. | Rongsheng Ma#, Qingfeng Li, Aidong Wang, Jiahai Zhang, Zhijun Liu, Jihui Wu, Xuncheng Su*, Ke Ruan*, Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer, Phys. Chem. Chem. Phys. 2016, 18(20): 13794-13798 |
