您当前的位置：首页 > 研究体系 > 分子与细胞生物物理研究部

刘钟华


lzh.jpg

姓　　名:

刘钟华

地　　址:

合肥微尺度物质科学国家研究中心，分子与细胞生物物理研究部，中国科学技术大学西校区生物楼

邮　　编:

230027

邮　　箱:

xixiaolu@ustc.edu.cn



/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

　教育与科研经历

2005年09月-2009年06月

西南大学，生物科学，学士

2009年09月-2015年06月

中国科学技术大学，结构生物学，博士

2015年04月-2021年11月

美国凯斯西储大学医学院病理系，博士后

2021年12月-2023年07月

美国凯斯西储大学医学院病理系，讲师

2023年07月-至今

中国科学技术大学合肥微尺度物质科学国家研究中心，特任研究员


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

　目前研究方向

　聚焦细胞命运决定，天然(固有)免疫炎症小体/细胞焦亡信号通路激活和调控的分子机制，以及对其干预的探索研究


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

　代表性论文 (https://www.ncbi.nlm.nih.gov/myncbi/zhonghua.liu.2/bibliography/public/)

1.

Li S, Bracey S, Liu Z (*), Xiao TS (*). Regulation of gasdermins in pyroptosis and cytokine release. Adv Immunol. 2023; 158:75-106. PubMed PMID: 37453754.

2.

Liu Z, Busscher BM, Storl-Desmond M, Xiao TS. Mechanisms of Gasdermin Recognition by Proteases. J Mol Biol. 2022 Feb 28; 434 (4):167274. PubMed PMID: 34599940; PubMed Central PMCID: PMC8844061.

3.

Liu Z, Xiao TS. Partners with a killer: Metabolic signaling promotes inflammatory cell death. Cell. 2021 Aug 19; 184 (17):4374-4376. PubMed PMID: 34416144; PubMed Central PMCID: PMC9847695.

4.

Liu Z, Wang C, Yang J, Chen Y, Zhou B, Abbott DW, Xiao TS. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. 2020 Jul 14; 53 (1):106-114.e5. PubMed PMID: 32553275; PubMed Central PMCID: PMC7382298.

5.

Srinivasan S (#), Liu Z (#), Chuenchor W, Xiao TS, Jankowsky E. Function of Auxiliary Domains of the DEAH/RHA Helicase DHX36 in RNA Remodeling. J Mol Biol. 2020 Mar 27; 432 (7):2217-2231. PubMed PMID: 32087197; PubMed Central PMCID: PMC7225076.

6.

Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS. Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Immunity. 2019 Jul 16; 51 (1):43-49.e4. PubMed PMID: 31097341; PubMed Central PMCID: PMC6640092.

7.

Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Sci Immunol. 2018 Aug 24; 3 (26). PubMed PMID: 30143556; PubMed Central PMCID: PMC6462819.

8.

Sun A, Li F, Liu Z, Jiang Y, Zhang J, Wu J, Shi Y. Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4. Protein Cell. 2018 Aug; 9 (8):738-742. PubMed PMID: 29134516; PubMed Central PMCID: PMC6053351.

9.

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Jun 26; 115 (26):6792-6797. PubMed PMID: 29891674; PubMed Central PMCID: PMC6042100.

10.

Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS. Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Structure. 2018 May 1; 26 (5):778-784. e3. PubMed PMID: 29576317; PubMed Central PMCID: PMC5932255.

11.

Yangyuoru PM, Bradburn DA, Liu Z, Xiao TS, Russell R. The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism. J Biol Chem. 2018 Feb 9; 293 (6):1924-1932. PubMed PMID: 29269411; PubMed Central PMCID: PMC5808756.

12.

Yang J, Liu Z, Xiao TS. Post-translational regulation of inflammasomes. Cell Mol Immunol. 2017 Jan; 14 (1):65-79. PubMed PMID: 27345727; PubMed Central PMCID: PMC5214939.

13.

Bao Y, Liu Z, Zhang J, Wu J, Shi Y. 1H, 13C and 15N resonance assignments and secondary structure of the human PHF6-ePHD1 domain. Biomol NMR Assign. 2016 Apr; 10 (1):1-4. PubMed PMID: 26286319.

14.

Liu Z, Xiao TS. STRUCTURAL BIOLOGY. Assembling the wheel of death. Science. 2015 Oct 23; 350 (6259): 376-7. PubMed PMID: 26494742; PubMed Central PMCID: PMC4668828.

15.

Liu Z, Li F, Zhang B, Li S, Wu J, Shi Y. Structural basis of plant homeodomain finger 6 (PHF6) recognition by the retinoblastoma binding protein 4 (RBBP4) component of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 2015 Mar 6; 290 (10): 6630-8. PubMed PMID: 25601084; PubMed Central PMCID: PMC4358295.

16.

Liu Z, Li F, Ruan K, Zhang J, Mei Y, Wu J, Shi Y. Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6. J Biol Chem. 2014 Apr 4; 289(14):10069-83. PubMed PMID: 24554700; PubMed Central PMCID: PMC3974978.

17.

Li S, Wandel MP, Li F, Liu Z, He C, Wu J, Shi Y, Randow F. Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy. Sci Signal. 2013 Feb 5; 6 (261): ra9. PubMed PMID: 23386746; PubMed Central PMCID: PMC3713453.


相关文章