李 赛
 | 姓 名: | 李赛 |
地 址: | 合肥微尺度物质科学国家研究中心，分子与细胞生物物理研究部，中国科学技术大学西区生物楼 | |
邮 编: | 230027 | |
邮 箱: | lisai@ustc.edu.cn |
| 教育与科研经历 |
2006.09 - 2010.07 | 安徽大学，本科 |
2010.09 - 2015.06 | 中国科学技术大学，博士 |
2016.02 - 2021.12 | 美国洛克菲勒大学，博士后 |
2022.01 - 2023.07 | 美国凯斯西储大学，博士后 |
2023.07 - | 中国科学技术大学，特任研究员 |
| 目前研究方向 |
| 运用单分子生物物理学和生物化学手段研究细胞内重要生物大分子的动力学机制。 |
| 代表性论文 |
1. | Sai Li; Michael R. Wasserman; Olga Yurieva; Lu Bai; Michael E. O’Donnell#; Shixin Liu#; Nucleosome-directed replication origin licensing independent of a consensus DNA sequence. Nature communications 2022, 13(1):4947. (Editors’ Highlights: “Structural biology, biochemistry and biophysics” and Faculty Opinions Recommended.) |
2. | Sai Li; Michael R. Wasserman; Olga Yurieva; Lu Bai; Michael E. O’Donnell#; Shixin Liu#; Origin recognition complex harbors an intrinsic nucleosome remodeling activity. Proceedings of the National Academy of Sciences of the United States of America 2022, 19(42): e2211568119. |
3. | Sai Li; Eric Bo Zheng; Li Zhao; Shixin Liu; Nonreciprocal and conditional cooperativity directs the pioneer activity of pluripotency transcription factors. Cell Reports 2019, 28(10): 2689-2703. |
4. | Sai Li; Syrena Bracey; Zhonghua Liu #; Tsan Sam Xiao#; Regulation of gasdermins in pyroptosis and cytokine release. Advances in Immunology 2023, 158:75-106. |
5. | Sai Li*; Michal P. Wandel*; Fudong Li; Zhonghua Liu; Chao He; Jihui Wu; Yunyu Shi #; Felix Randow #; Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor Galectin-8 in antibacterial autophagy. Science Signaling 2013, 6 (261):ra9. (Faculty of 1000 Microbiology recommended and Science Signaling podcast highlighted) |
6. | Tuan Nguyen; Sai Li; Jeremy T-H Chang; John W Watters; Htet Ng; Adewola Osunsade; Yael David; Shixin Liu; Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA. Nature communications 2022, 13(1): 3988. (Editors’ Highlights: “Genetics, Genomics and Epigenetics”) |
7. | Xiaocong Cao; Kaixian Liu; Shannon Yan; Sai Li; Yajuan Li; Tengchuan Jin#; Shixin Liu #; Mechanical regulation of the helicase activity of Zika virus NS3. Biophysical Journal 2022, 121(24):4900-4908. |
8. | Zhonghua Liu; Fudong Li; Beibei Zhang; Sai Li; Jihui Wu#; and Yunyu Shi#; Structural basis of plant homeodomain finger 6 (PHF6) recognition by the retinoblastoma binding protein 4 (RBBP4) component of the nucleosome remodeling and deacetylase (NuRD) complex. Journal of Biological Chemistry 2015, 290(10): 6630-6638. |
9. | Wenjuan Zhang; Fuxing Zeng; Yiwei Liu; Chen Shao; Sai Li; Hui Lv; Yunyu Shi; Liwen Niu; Maikun Teng#; and Xu Li#; Crystal structure of human SSRP1 middle domain reveals a role in DNA binding. Scientific Reports 2015, 5: 18688. |
10. | Juncheng Wang; Su Qin; Fudong Li; Sai Li; Wei Zhang; Junhui Peng; Zhiyong Zhang; Qingguo Gong; Jihui Wu#; and Yunyu Shi#; Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding. Cell Research 2014, 24(7):890-893.(* equal contribution; # corresponding author) |
