涂晓明


/uploads/image/2019/04/09/c1c36e22886b8a90091323c8bfd94d59.jpg 姓  名: 涂晓明
 出生日期: 1976年3月出生于福建
 地  址:合肥微尺度物质科学国家研究中心,中国科学技术大学生命科学学院
 实验室网页:http://bionmr.ustc.edu.cn/tulab/
 电  话:86-551-3600757(o)
 传  真:86-551-3600757
 电子邮箱:xmtu@ustc.edu.cn




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 教育与科研经历

  涂晓明,博士,副教授,博士生导师,男,合肥微尺度物质科学国家研究中心,中国科学技术大学生命科学学院。 2012年获中国科学院卢嘉锡青年人才奖。共发表SCI论文39篇,其中以第一作者或通讯作者在Molecular Biology of the Cell,Journal of Cell Science,Journal of Biological Chemistry,Biochemical Journal,Scientific Reports等重要国际学术期刊发表研究论文29篇。 


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 目前研究方向
  1.锥体虫基因表达调控和细胞周期调控的分子机制研究;
  2.Ubiquitin家族蛋白的结构和功能的研究;
  3.重要蛋白或蛋白结构域的结构和功能的研究。


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 在研科研项目
  1.国家重大科学研究计划项目(973)子课题, 执行期限:2009-2013年,课题负责人;
  2.中国科学院“生命科学领域优秀青年科技专项”,执行期限:2011-2013年,项目负责人;
  3.国家自然科学基金面上项目,执行期限:2013-2016年,项目负责人;
  4.国家自然科学基金联合基金项目,执行期限:2014-2016年,项目负责人。


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 代表性论文
  1.Shanhui Liao, Wen Zhang, Kai Fan, Kaiqin Ye, Xuecheng Zhang, Jiahai Zhang, Chao Xu and Xiaoming Tu* (2013). Ionic strength-dependent conformations of a ubiquitin-like small archaeal modifier protein (SAMP2) from Haloferax volcanii. Scientific Reports. 3, 2136. (*通讯作者)
  2.Tao Wang, Jiahai Zhang, Xuecheng Zhang, Chao Xu and Xiaoming Tu* (2013). Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module. Scientific Reports. 3, 1079.
  3.Yu Qiu, Wen Zhang, Chen Zhao, Yan Wang, Weiwei Wang, Jiahai Zhang, Zhiyong Zhang, Guohong Li, Yunyu Shi, Xiaoming Tu* and Jihui Wu* (2012) Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA. Biochemical Journal. 442: 527-538.
  4.Wen Zhang, Jiahai Zhang, Xuecheng Zhang, Chao Xu and Xiaoming Tu* (2011) Solution structure of Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae. Biochemical Journal. 436: 83-90.
  5.Shanhui Liao, Qiang Shang, Xuecheng Zhang, Jiahai Zhang, Chao Xu, Xiaoming Tu* (2009) Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein. Biochemical Journal. Accelerated Publication. 422: 207-215.
  6.Xiaoming Tu, Praveen Kumar, Ziyin Li and Ching C. Wang (2006) An Aurora Kinase Homologue is Involved in Mitosis and Cytokinesis in Trypanosoma brucei. J. Biol. Chem. 281:9677-9687.
  7.Xiaoming Tu, Joel Mancuso, W. Zacheus Cande and Ching C. Wang (2005) Distinct cytoskeletal modulation and regulation of G1-S transition in the two life stages of Trypanosoma brucei. Journal of Cell Science. 118:4353-4364.
  8.Xiaoming Tu and Ching C. Wang (2005) Coupling of Posterior Cytoskeletal Morphogenesis to the G1/S Transition in the Trypanosoma brucei Cell Cycle. Molecular Biology of the Cell. 16:97-105.
  9.Xiaoming Tu and Ching C. Wang (2004) The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion. J. Biol. Chem. 279:20519-20528.


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