宋晓元


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姓  名:

宋晓元 教授,博导

地  址:

安徽省合肥市中国科学技术大学生命学院

电  话:

0551-63607752

电  邮:

songxy5@ustc.edu.cn




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 教育与科研经历

1996年毕业于北京师范大学生物系,1999年取得分子细胞生物学硕士学位。

2006年在美国罗彻斯特大学生物系取得分子、细胞和发育生物学博士学位。

2006-2012年在加州大学圣地亚哥分校进行博士后研究,期间获得癌症研究所博士后奖学金。

2013年加入中国科学技术大学生命科学学院。

多年来一直从事基因表达调控、表观遗传学,ncRNA,基因组相互作用等相关研究,在 GenesDev. 、Mol Cell Biol.、Nature、PNAS 等

学术期刊上发表了系列文章。


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 主要研究成果

  主要研究由长链非编码RNA (lncRNA) 和三维基因组结构所组成的三维转录调控在脑衰老以及精子发生过程中的作用。提出了lncRNA介导染色质相互作用构成转录的三维空间调控模型(Protein Cell 2015),并在脑衰老等生命过程中进行验证。首次报道了单细胞模式动物四膜虫大、小核不同的三维基因组结构并发现了大核染色体形成的机制(Genome Research 2020)。解析了四膜虫减数分裂上游master分子CYC2的功能(Protein Cell 2016),也揭示了哺乳动物小鼠精子发生过程中三维基因组结构的动态变化。合作发现保守的lncRNA簇(CNIB1)在发育和视觉中的功能(NAR 2019)。


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 主要研究兴趣

1.

研究由lncRNA和三维基因组结构所组成的三维转录调控在脑衰老中的作用

2.

研究lncRNA和染色质相互作用在精子发生过程中的转录调控作用

3.

研究减数分裂相关特定基因的功能及其分子机制


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 代表性论文

1.

Luo Z.*, Hu T. *, Jiang H., Wang R., Xu Q., Zhang S., Cao J., Song X.#. Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila. Genome Research. 2020. Mar 12. doi: 10.1101/gr.241687.118. #Corresponding author.

2.

Cheng Q.*, Ouyang X.*, Zhang R.*, Zhu L., Song X.#. Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. RNA Biology. 2020. Jan 30: 1-14. #Corresponding author.

3.

Cao J., Jiang H.*, Zhang R.*, Ghanam AR.*, Xia H., Zhu Y., Yang Z., Song X.#. Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance. Science Bulletin. 2019. 64: 1132-1135. #Corresponding author.

4.

Ghanam AR., Cao J., Ouyang X., and Song X.#. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019. 2818415. eCollection 2019. #Corresponding author.

5.

Wang F.*, Ren D.*, Liang X.*, Ke S., Zhang B., Hu B.#, Song X.#, Wang X.#. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019, 47(12): 6315-6329. #Corresponding author.

6.

Mamun M.Al., Mannoor K., Cao J., Qadri F., Song X.#. SOX2 in cancer stemness: Tumor malignancy and therapeutic potentials. Journal of Molecular Cell Biology. 2018. doi: 10.1093/jmcb/mjy080. #Corresponding author.

7.

Ghanam AR., Xu Q., Ke Sh., Azhar M., Cheng Q., Song X.#. Shining the light on senescence associated lncRNAs. Aging & Disease. 2017, 1; 8(2):149-161. #Corresponding author.

8.

Xu Q., Wang R., Ghanam AR., Yan G., Miao W., Song X.#. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein & Cell. 2016, 7(4):236-49. #Corresponding author.

9.

Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.#. Three-dimensional regulation of transcription. Protein & Cell. 2015, 6(4):241-53. #Corresponding author.

10.

Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.#. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29.

11.

Song X.*, Wang X.*, Arai S. and Kurokawa R.#. Promoter-associated noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. *Co-first author.

12.

Harismendy O.*, Notani D.*, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG#, and Frazer KA#. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. *Co-first author.

13.

Wang X.* and Song X.*, Glass CK., and Rosenfeld MG#. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol. 2011 3(1):a003756. *Co-first author. Collected in《The RNA World》IV.

14.

Wang X., Arai S.*, Song X.*, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.#, Glass CK.#, and Kurokawa R.#. Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription. Nature. 2008, 454(7200):126-30.

15.

Song, X.*, Gjoneska E.*, Ren Q.*, Taverna SD., Allis C.D., and Gorovsky MA.#. Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. *Co-first author.

16.

Song X. and Gorovsky MA.#. Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation. Mol Cell Biol. 2007, 27(5):1925-33.

17.

Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.#. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9.


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