王 朝


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姓  名:

王朝

地  址:

安徽合肥市黄山路443号中国科学技术大学

邮  编:

230027

电  话:

0551-63603495

电  邮:

cwangust@ustc.edu.cn




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 教育与科研经历

教育经历:

2005/09-2009/06

上海交通大学,学士,生物工程

2009/08-2014/06

香港科技大学,博士,生物化学

工作经历:

2014/07-2016/02

香港科技大学,博士后

2016/03-至今

中国科学技术大学生命科学学院,研究员


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 目前研究方向


  王朝,男,中国科学技术大学生命科学与医学部研究员,博士生导师。中国科学院率先行动 “百人计划”入选者。2009年本科毕业于上海交通大学生命科学技术学院,2014年博士毕业于香港科技大学生物化学系,师从著名神经结构生物学家张明杰院士。2016 年加入中国科学技术大学,组建神经结构化学生物学实验室。近年来在Nat Chem Biol (2018)、Nat Commun (2021)、PNAS (2020,2021) 等杂志发表通讯作者文章。主持国家自然科学基金面上项目、国家自然科学基金重大研究计划培育项目等,获得科技部重点研发计划“蛋白质机器与生命过程调控”重点专项资助。
  主要研究方向为神经结构化学生物学,通过系统性地研究神经系统中重要的支架蛋白介导的蛋白复合物的结构功能和化学生物学调控,来深入理解神经细胞极性建立与维持,以及神经网络环路调控的分子机制,并为神经系统疾病的发病机理和药物开发等提供理论基础。


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 代表性论文

1.

Ye J#, Zou G#, Zhu R, Kong C, Miao C, Zhang M, Li J*, Xiong W*, and Wang C*. (2021). Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nat Commun. 12:297.

2.

Zhang M#, Lin L#, Wang C*, and Zhu J*. (2021). Double inhibition and activation mechanisms of Ephexin family RhoGEFs. PNAS. In press.

3.

Ye J#, Li J#, Ye F, Zhang Y, Zhang M, and Wang C*. (2020). Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance. PNAS. 117(2):1207-1215.

4.

Li J#, Zhu R#, Chen K, Zheng H, Zhao H, Yuan C, Zhang H*, Wang C*, and Zhang M*. (2018). Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins. Nat Chem Biol. 14(8):778–787.

5.

Wang M#, Lin L#, Shi Y, He L, Wang C*, and Zhu J*. (2020). Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. Biochem J. 477(23):4623-4634.

6.

Nelson AD, Caballero-Florán RN, Rodríguez Díaz JC, Hull JM, Yuan Y, Li J, Chen K, Walder KK, Lopez-Santiago LF, Bennett V, McInnis MG, Isom LL, Wang C, Zhang M, Jones KS, and Jenkins PM*. (2020). Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry. 25(11):2800-2817.

7.

Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S*, Pan Y*, Jiang W*, and Zhou R*. (2020). Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol. 22(6):716-727.

8.

Lin L, Shi Y, Wang M, Wang C, Zhu J*, and Zhang R*. (2019). Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase. Structure. 27(5):729-740.

9.

Zhu W#, Wang C#, Hu J#, Wan R, Yu J, Xie J, Ma J, Guo L, Ge J, Qiu Y, Chen L, Liu H, Yan X, Liu X, Ye J, He W, Shen Y, Wang C, Mohler PJ*, and Hong K*. (2018). Ankyrin-B Q1283H variant linked to arrhythmias via loss of local protein phosphatase 2A activity causes ryanodine receptor hyperphosphorylation. Circulation. 138(23):2682-2697.

10.

He H#, Jiang H#, Chen Y#, Ye J, Wang A, Wang C, Liu Q, Liang G, Deng X*, Jiang W*, and Zhou R*. (2018). Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 9(1):2550.

11.

Jiang H#, He H#, Chen Y#, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W*, Deng X*, and Zhou R*. (2017). Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 214(11):3219-3238.

12.

Chen K#, Li J#, Wang C, Wei Z, and Zhang M. (2017). Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions. eLife. 6:e29150.

13.

Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, and Arbour LT. (2017). Novel Variant in the ANK2 Membrane-Binding DomainIs Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome. Circ Cardiovasc Genet. 10(1). pii: e001537.

14.

Lorenzo DN, Healy JA, Hostettler J, Davis J, Yang J, Wang C, Hohmeier HE, Zhang M, and Bennett V. (2015). Ankyrin-B metabolic syndrome: age-dependent adiposity combined with primary pancreatic beta-cell insufficiency. J Clin Invest. 125(8):3087-3102.

15.

Wang C#, Wei Z#, Chen K, Ye F, Yu C, Bennett V, and Zhang M*. (2014). Structural basis of diverse membrane target recognitions by ankyrins. eLife. 3:e04353.

16.

Wang C, Yu C, Ye F, Wei Z*, and Zhang M*. (2012). Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function. PNAS. 109 (13):4822-4827.


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