张志勇
 | 姓 名: | 张志勇 |
地 址: | 安徽省合肥市黄山路443号中国科技大学生命学院 | |
邮 编: | 230026 | |
电 话: | 0551-63600854 | |
电 邮: | zzyzhang@ustc.edu.cn | |
主 页: | https://biox.ustc.edu.cn/2015/0713/c692a3269/page.htm |
| 教育与科研经历 |
1994年9月至1998年7月 | 就读于中国科学技术大学生物系，分子与细胞生物学学士学位 |
1998年9月至2003年7月 | 在中国科学技术大学生命科学学院免试硕博连读，生化与分子生物学博士学位，获“求是”及“中国科学院院长”奖 |
2003年12月至2006年12月 | 在美国得克萨斯休斯顿健康科学中心从事博士后研究，期间获得Keck Center Pharmacoinformatics Fellowship资助 |
2006年12月至2010年3月 | 在犹他大学化学系从事博士后研究 |
2010年4月至2010年12月 | 在芝加哥大学化学系从事博士后研究 |
2010年6月至今 | 通过中国科技大学优秀人才引进，受聘为生命科学学院教授 |
| 目前研究方向 |
1. | 发展生物大分子多尺度模拟的新方法，如构象空间增强采样技术和粗粒化模拟，等等； |
2. | 多尺度模拟整合核磁共振、冷冻电镜以及X射线小角散射等结构数据，研究生物大分子（蛋白、核酸及复合物）的结构及动态变化。 |
| 代表性论文 |
1. | Junhui Peng#, Chuang Yuan#, Rongsheng Ma, Zhiyong Zhang*. Backmapping from multiresolution coarse-grained models to atomic structures of large biomolecules by restrained molecular dynamics simulations using Bayesian inference. Journal of Chemical Theory and Computation 2019 (15): 3344-3353 |
2. | Zilong Wang, Shuang Wang, Zheng Xu, Mingwei Li, Kuan Chen, Yaqun Zhang, Zhimin Hu, Meng Zhang, Zhiyong Zhang*, Xue Qiao*, Min Ye*. Highly promiscuous flavonoid 3-O-glycosyltransferase from Scutellaria baicalensis. Organic Letters 2019 (21): 2241-2245 |
3. | Chun Ye, Chengtao Ding, Rongsheng Ma, Junfeng Wang, Zhiyong Zhang*. Electrostatic interactions determine entrance/release order of substrates in the catalytic cycle of adenylate kinase. Proteins 2019 (87): 337-347 |
4. | Difei Xu, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang*, Ke Ruan*. Dynamic nature of CTCF tandem 11 zinc fingers in multivalent recognition of DNA as revealed by NMR Spectroscopy. The Journal of Physical Chemistry Letters 2018 (9): 4020-4028 |
5. | Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu*, Zhiyong Zhang*. Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies. Physical Chemistry Chemical Physics 2017 (19): 21152-21164 |
6. | Peng Cheng#, Junhui Peng#, Zhiyong Zhang*. SAXS-oriented ensemble refinement of flexible biomolecules. Biophysical Journal 2017 (112): 1295-1301 |
7. | Junhui Peng, Zhiyong Zhang*. Unraveling low-resolution structural data of large biomolecules by constructing atomic models with experiment-targeted parallel cascade selection simulations. Scientific Reports 2016 (6): 29360 |
8. | Yonghui Zhang, Junhui Peng, Zhiyong Zhang*. Structural modeling of proteins by integrating small-angle X-ray scattering data. Chinese Physics B 2015 (24): 126101 |
9. | Junhui Peng, Debiao Zhao, Bin Wen, Zhiyong Zhang*. Determining structural models of biomolecular complexes integrating nuclear magnetic resonance, small-angle X-ray scattering and computational simulations. Chinese Journal of Magnetic Resonance 2015 (32): 181-194 |
10. | Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang*. Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations. Protein & Cell 2015(6): 619-623 |
11. | Zhiyong Zhang*. Systematic methods for defining coarse-grained maps in large biomolecules. Advances in Structural Bioinformatics 2015 (827): 33-48 |
