王雪娟


/uploads/image/2019/03/20/0e6da69bbed0133106eab59ab554dfe1.png 姓  名: 王雪娟
 地  址: 安徽省合肥市黄山路中国科学技术大学 生命科学学院
 邮  编:230027
 电  话:0551-63603802
 电  邮:xuejuan@ustc.edu.cn




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 教育与科研经历
  2001/09-2006/07复旦大学公共卫生学院,学士
  2008/09-2010/05

美国圣地亚哥州立大学,生物统计,硕士

  2012/09-2015/07南京农业大学,生命科学学院,博士
  2013/04-2016/03中国科学技术大学,助理研究员
  2016/04-2018/03中国科学技术大学,特任副研究员
  2018/04-至今中国科学技术大学,特任研究员


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 目前研究方向

利用冷冻电镜解析DNA双链断裂(DSB)早期信号传导和减数分裂联会复合体动态组装的分子机制。


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 代表性论文
  1.Wang, X#., Ran, T#., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*. 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science, 358, 1206, 2017
  2.Wang, X*., Ahmad, S., Zhang, Z., Côté, J., Cai, G*. Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications 9, 1147, doi: 10.1038/s41467-018-03504-5, 2018
  3.Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*. Architecture of SWI/SNF chromatin remodeling complex. Protein Cell,(DOI 10.1007/s13238-018-0524-9) 2018
  4.Zhang X., Wang, X*., Zhang Z.,  Cai, G*. (2019) Structure and Functional Interactions of INO80 Actin/Arp Module, J Mol Cell Biol (doi: 10.1093/jmcb/mjy062)
  5.Wang, X., Chu, H., Lv M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*, Cai, G*. Structure of the intact ATM/Tel1 kinase. Nature Communications 7, 11655, doi:10.1038/ncomms11655
  6.Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G*. Redefine the Modular Organization of the Core Mediator Complex. Cell Research 24: 796-808, 2014
  7.Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G*. Structural flexibility and functional interaction of Mediator Cdk8 module. Protein Cell 4, 911-920, 2013
  8.Lan P., Tan M., Zhang Y., Niu S., Chen J., Shi S., Qiu S., Wang X., Peng X., Cai G., Cheng H., Wu J., Li G., Lei M. Structural insight into precursor tRNA processing by yeast ribonuclease P , Science, 362, 657, 2018
  9.Zhao D, Wang X, Peng J, Wang C, Li F, Sun Q, Zhang Y, Zhang J, Cai G, Zuo X, Wu J, Shi Y, Zhang Z*, Gong Q*. Structural investigation of the interaction between the tandem SH3 domains of c-Cb1-associated protein and vinculin. Journal of Structural Biology 187(2):194-205, 2014
  10.Liu Z, Chen P, Wang X, Cai G, Niu L, Teng M, Li X. Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res 42(14):9470-83, 2014
  11.Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW, Chen Y, Zhou CZ., Structural basis for receptor recognition and pore formation of a zebrafish aerolysin‐like protein. EMBO Rep 17(2):235-48, 2016


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