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郑基深


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姓　　名:

郑基深

地　　址:

安徽省合肥市蜀山区黄山路443号  中国科学技术大学生命学院

邮　　编:

230027

电　　话:

86-551-63600795

电　　邮:

jszheng@ustc.edu.cn

主　　页:

https://biox.ustc.edu.cn/2018/0629/c691a268506/page.htm



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　教育与科研经历

2002.9 - 2006.7

中国科学技术大学，化学与材料科学学院，本科

2006.9 - 2012.7

中国科学技术大学，化学与材料科学学院，博士

2012.7 - 2014.3

清华大学，生命科学联合中心，博士后

2014.3 - 2016.7

中国科学院，强磁场科学中心，副研究员

2016.7 - 至今

中国科学技术大学，生命科学学院，研究员


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　目前研究方向

主要研究方向是膜蛋白化学合成与外源分子调控。以重要生物学问题和重大疾病密切相关的膜蛋白为研究对象，发展了可脱除主链骨架修饰（RBM）策略，结合蛋白质化学合成技术，实现一系列具有生物活性的膜蛋白体外重构，例如定点翻译后修饰、定点同位素标记等功能化膜蛋白。同时，基于高通量筛选技术进行天然蛋白配体分子的功能进化，发现新的D-型多肽类活性分子/药物前体分子，开发靶向膜蛋白的蛋白质探针工具，结合现代生物化学和生物物理技术，阐释跨膜蛋白结构-功能机制，实现膜蛋白功能的精确调控，并开发靶向膜蛋白的新型D-多肽类药物分子。在Nature Commun、Nature Protocols、J Am Chem Soc、Angew Chem Int Ed和Acc Chem Res等国际高水平杂志发表（共同）通讯/第一作者论文30余篇。


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　代表性论文

1.

Qu, Q.; Gao, S.; Wu, F. M.; Zhang, M. G.; Li, Y; Zhang, L. H.,  Donald Bierer, Tian, C. L.*, Zheng, J. S.*; Liu, L.*, Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges through a native chemical ligation-assisted diaminodiacid strategy. Angew. Chem. Int. Ed. 2020, 59, 10.1002/anie.201915358.

2.

Huang, D. L.; Montigny, C.; Zheng, Y.; Beswick, V.; Li, Y.; Cao, X. X.; Barbot, T.; Jaxel, C.; Liang, J.; Tian, C. L.; Jamin, N.; Zheng, J. S.*. Chemical Synthesis of Native S-palmitoylated Membrane Proteins through Reversible Backbone Modification Assisted Ser/Thr Ligation. Angew. Chem. Int. Ed. 2020, 59, 10.1002/anie.201914836.

3.

Zhang, B.; Deng, Q.; Zuo, C.; Yan, B.; Zuo, C.; Cao, X. X.; Zhu, T. F.; Zheng, J. S.*; Liu, L.*, Ligation of Soluble but Unreactive Peptide Segments in the Chemical Synthesis of Haemophilus Influenzae DNA Ligase. Angew. Chem. Int. Ed. 2019, 58, 12231-12237.

4.

Qi, Y.-K.; Si, Y.-Y.; Du, S.-S.; Liang, J.; Wang, K.-W.*; Zheng, J. S.*, Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and probes. Science China Chemistry 2019, 62 (3), 299-312.

5.

Guo, Q. Y.; Zhang, L. H.; Zuo, C.; Huang, D. L.; Wang, Z. A.;   Zheng, J. S.*; Tian, C. L.*, Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors. Protein Cell 2019, 10, 211-216.

6.

Tang, S.; Liang, L. J.; Si, Y. Y.; Gao, S.; Wang, J. X.; Liang, J.; Mei, Z.; Zheng, J. S.*; Liu, L.* Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide-Linked Ub Isomer. Angew. Chem. Int. Ed. 2017, 56, 13333-13337.

7.

Tang, S.; Zuo, C.; Huang, D. L.; Cai, X. Y.; Zhang, L. H.; Tian, C. L.*; Zheng, J. S.*; Liu, L.* Chemical Synthesis of Membrane Proteins via the Removable Backbone Modification Method. Nature Protocols 2017, 12, 2554-2569.

8.

Li, J. B.; Tang, S.; Zheng, J. S.*; Tian, C. L.*; Liu, L.* Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins. Acc. Chem. Res. 2017, 50, 1143-1153.

9.

Zheng, J.-S.; He, Y.; Zuo, C.; Cai, X. Y.; Tang, S.; Wang, Z. A.; Zhang, L.-H., Tian, C.-L.*; Liu, L.* Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification. J. Am. Chem. Soc. 2016, 138, 3553-3561.

10.

Chen, X. Tang, S.; Zheng, J. S.; Zhao, R.; Wang, Z. P.; Shao, W.; Chang, H. N.; Cheng, J. Y.; Zhao, H.; Liu, L.*; Qi, H.* Chemical Synthesis of a Two-Photon-Activatable Chemokine and Photon-Guided Lymphocyte Migration in vivo. Nat. Commun. 2015, 6, 7220-7228.

11.

Zheng, J.-S.; Yu, M.; Qi, Y.-K.; Tang, S.; Shen, F.; Wang, Z.-P.; Xiao, L.; Zhang, L.; Tian, C.-L.*; Liu, L.* Expedient Total Synthesis of Small to Medium-Sized Membrane Proteins via Fmoc Chemistry. J. Am. Chem. Soc. 2014, 136, 3695-3704.

12.

Zheng, J.-S.; Tang, S.; Qi, Y.-K.; Wang, Z.-P.; Liu, L.* Chemical Synthesis of Proteins Using Peptide Hydrazides as Thioester Surrogates. Nat. Protoc. 2013, 8, 2483-2495.

13.

Zheng, J.-S.; Tang, S.; Huang, Y.-C.; Liu, L.* Development of New Thioester Equivalents for Protein Chemical Synthesis. Acc. Chem. Res. 2013, 46, 2475–2484.

14.

Zheng, J.-S.; Chang, H.-N.; Wang, F.-L.; Liu, L.* Fmoc Synthesis of Peptide Thioesters without Post-Chain-Assembly Manipulation. J. Am. Chem. Soc. 2011, 133, 11080-11083.


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