 | 姓 名: | 薛 林 |
地 址: | 中国科学技术大学生命科学学院 | |
邮 编: | 230027 | |
电 邮: | linxue@ustc.edu.cn | |
主 页: | https://faculty.ustc.edu.cn/xuelin/zh_CN/index.htm |
| 教育与科研经历 |
2000-2004 | 河北大学，化学，学士 |
2004-2007 | 南开大学，无机化学，硕士 |
2007-2010 | 中国科学院化学研究所，有机化学，博士 |
2010-2013 | 中国科学院化学研究所，助理/副研究员 |
2013-2017 | 瑞士洛桑联邦理工学院，博士后 |
2017-2021 | 德国马克思普朗克医学研究所，博士后 |
2021-2022 | 中国科学技术大学生命科学与医学部，特任研究员 |
2022-至今 | 中国科学技术大学生命科学与医学部，特任教授 |
| 研究方向 |
1. | 基于蛋白工程及蛋白标记的生物传感技术 |
2. | 小分子荧光染料/探针的合成及生物应用 |
3. | 代谢相关生物传感器的开发与代谢通路解析 |
| 代表性论文 |
1. | Xinci Wang, Lihao Ding, Jiang Liu, Jiahui Lv, Junjie Liu, Yu Yan, Xutong Li, Huan Shi, Hui Wang, Jiajia Wang, Senquan Liu*, Duanhua Cao*, Xinxing Yang*, Lin Xue*. A General Strategy for High-Efficiency Live Bacteria Imaging and Targeted Phototherapy. Chem. Sci. 2026, 17, 12940–12959. |
2. | Lihao Ding, Xinci Wang, Jiajia Wang, Hui Wang, Le Yu, Jiang Liu, Jiangliu Yu, Ting Xue, Xinxing Yang*, Lin Xue*. Fluorogenic Probes for Real-Time Tracking of Bacterial Cell Wall Dynamics with Nanoscopy. ACS Nano. 2025, 19, 14389–14403. |
3. | Dongjian Zhu, Aishan Ren*, Lin Xue*. A Mitochondria-Targeted Colorimetric and NIR Ratiometric Fluorescent Probe for Biothiols with Large Stokes Shift based on Thiol-chromene Click Reaction. Org. Biomol. Chem. 2024, 22, 9113–9120. |
4. | Lin Xue*, Paul Schnacke, Michelle S. Frei, Birgit Koch, Julien Hiblot, Richard Wombacher, Sebastian Fabritz, Kai Johnsson*. Probing Coenzyme A Homeostasis with Semisynthetic Biosensors. Nat. Chem. Biol. 2023, 19, 346–355. |
5. | Lin Xue, Qiuliyang Yu, Rudolf Griss, Alberto Schena, Kai Johnsson*. Bioluminescent Antibodies for Point-of-Care Diagnostics. Angew. Chem. Int. Ed. 2017, 56, 7112−7116. |
6. | Lin Xue, Efthymia Prifti, and Kai Johnsson*. A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range. J. Am. Chem. Soc. 2016, 138, 5258−5261. |
7. | Lin Xue, Iuliia A Karpenko, Julien Hiblot, Kai Johnsson*. Imaging and Manipulating Proteins in Live Cells Through Covalent Labeling. Nat. Chem. Biol. 2015, 11, 917–923. |
8. | Guoping Li, Dongjian Zhu, Qing Liu, Lin Xue*, Hua Jiang*. A Strategy for Highly Selective Detecting and Imaging Hypochlorite Using Selenoxide Elimination. Org. Lett. 2013, 15, 2002−2005. |
9. | Guoping Li, Dongjian Zhu, Qing Liu, Lin Xue*, Hua Jiang*. Rapid Detection of Hydrogen Peroxide Based on Aggregation Induced Ratiometric Fluorescence Change. Org. Lett. 2013, 15, 924−927. |
10. | Guoping Li, Dongjian Zhu, Lin Xue*, Hua Jiang*. Quinoline-based Fluorescent Probe for Ratiometric Detection of Lysosomal pH. Org. Lett. 2013, 15, 5020–5023. |
11. | Dongjian Zhu, Guoping Li, Lin Xue*, Hua Jiang*. Development of Ratiometric Near-Infrared Fluorescent Probes using Analyte-Specific Cleavage of Carbamate. Org. Biomol. Chem. 2013, 11, 4577−4580. |
12. | Qing Liu, Guoping Li, Dongjian Zhu, Lin Xue*, Hua Jiang*. Design of Quinoline-based Fluorescent Probe for the Ratiometric Detection of Cadmium in Aqueous Media. Chin. Chem. Lett. 2013, 24, 479−482. |
