 | 姓 名: | 刘 强 |
地 址: | 安徽省合肥市黄山路443号 | |
邮 编: | 230027 | |
电 话: | 0551-63601179 | |
电 邮: | Liuq2012@ustc.edu.cn |
| 个人介绍 |
国家杰出青年科学基金获得者（2021），国家创新人才计划（2012），国家优秀青年科学基金获得者（2014）。长期从事学习记忆，神经退行性疾病以及脑衰老等方面的研究工作，并致力于解析表观遗传调控在脑衰老和神经退行性疾病中的作用机制。近年来取得了一系列重要研究成果，发表于Cell, Neuron, Nature Structural & Molecular Biology，Cell Metabolism, Trends in Neurosciences等国际学术期刊。 |
| 主要研究兴趣 |
1. 脑衰老和阿尔茨海默病的分子细胞机制探索 2. 大脑脂代谢在神经退行性疾病以及衰老过程中的作用机制研究 3. 表观遗传调控在学习记忆中的作用机制解析 |
| 代表性研究论文 |
1. | Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q. Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization. Cell Metabolism 36: 1-17, 2024. |
2. | Li D, Cao R, Li Q, Yang Y, Tang A, Zhang J, Liu Q. Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment. Nature Structural & Molecular Biology 30:914-925, 2023. |
3. | Li XH, Zhang J, Li DF, He C, He K, Xue T, Wan L, Zhang C and Liu Q. Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone acetylation-mediated memory. Neuron 109:957-970, 2021. |
4. | Li D, Zhang J, Liu Q. Brain cell type-specific cholesterol metabolism and implications for learning and memory. Trends in Neurosciences 45:401-414, 2022. |
5. | Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L and Liu Q. Activity dependent LoNA Regulates Translation by Coordinating rRNA Transcription and Methylation. Nature Communications 9（1）：1726，2018. |
6. | Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q. SFRS11 loss leads to aging-associated cognitive decline by modulating LRP8 and ApoE. Cell Reports 28(1):78-90, 2019. |
7. | Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q. Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing. Molecular Neurodegeneration 16(1):66, 2021. |
8. | Zhang J, Liu Q. Age- and disease-related memory decline: epigenetic biomarker and treatment. Science Bulletin 68(16):1719-1721, 2023. |
9. | Zhang J, Li D, He K, Liu Q*, Xie Z*. Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain. Protein & Cell 15(2):149-155，2024. |
10. | Li D, Zhang J, Liu Q. Mechanistic insights on non-coding RNAs in learning and memory. Science Bulletin. 68(15):1591-1594, 2023. |
11. | Zhang J, Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein & Cell. 6(4):254-64，2015. |
