2011年5月6日，我室低维物理与化学研究部龚流柱教授研究组在ORGANIC LETTERS上发表题为Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A的论文。

Source: ORGANIC LETTERS Volume: 13 Issue: 9 Pages: 2418-2421 Published: MAY 6 2011
Chang MN (Chang, Mou-Nuo), Wang H (Wang, Hao), Gong LZ (Gong, Liu-Zhu)1
Addresses:
1. Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China
2. Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China
E-mail Addresses: gonglz@ustc.edu.cn

Reprint Address: Gong, LZ (reprint author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

Abstract: The total synthesis of two diastereomers of spirotryprostatin A has been established starting with an asymmetric 1,3-dipolar cycloaddition of methyl 2-(2-nitrophenyl)acrylate with azomethine ylides catalyzed by a Bronsted acid.