2011年4月12日，我室生物大分子结构与功能研究部姚雪彪教授研究组与哈佛大学等单位合作在CANCER CELL上发表题为CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3的论文。

Source: CANCER CELL Volume: 19 Issue: 4 Pages: 541-555 Published: APR 12 2011
Chen JQ (Chen, Jingqi)3,4, Yao YD (Yao, Yandan)4, Gong C (Gong, Chang)4, Yu FY (Yu, Fengyan)4, Su SC (Su, Shicheng)4, Chen JN (Chen, Jianing)4, Liu BD (Liu, Bodu)4, Deng H (Deng, Hui)1,2, Wang FS (Wang, Fengsong)1,2, Lin L (Lin, Ling)4, Yao HR (Yao, Herui)4, Su FX (Su, Fengxi)4, Anderson KS (Anderson, Karen S.)5, Liu QA (Liu, Qiang)4,5, Ewen ME (Ewen, Mark E.)5, Yao XB (Yao, Xuebiao)1,2, Song EW (Song, Erwei)4
Addresses:
1. Hefei Natl Lab Phys Sci Nanoscale, Anhui Key Lab Cellular Dynam & Chem Biol, Hefei 230027, Anhui Peoples R China
2. Univ Sci & Technol China, Hefei 230027, Anhui Peoples R China
3. Guangzhou Med Coll, Affiliated Hosp 2, Dept Med Oncol, Guangzhou 510260, Guangdong Peoples R China
4. Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510120, Guangdong Peoples R China
5. Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
E-mail Addresses: yaoxb@ustc.edu.cn, songerwei02@yahoo.com.cn

Reprint Address: Yao, XB (reprint author), Hefei Natl Lab Phys Sci Nanoscale, Anhui Key Lab Cellular Dynam & Chem Biol, Hefei 230027, Anhui Peoples R China

Abstract: Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis, but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival. CCL18 released by breast TAMs promotes the invasiveness of cancer cells by triggering integrin clustering and enhancing their adherence to extracellular matrix. Furthermore, we identify PITPNM3 as a functional receptor for CCL18 that mediates CCL18 effect and activates intracellular calcium signaling. CCL18 promotes the invasion and metastasis of breast cancer xenografts, whereas suppressing PITPNM3 abrogates these effects. These findings indicate that CCL18 derived from TAMs plays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.