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姚雪彪


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　Name:Xuebiao Yao（X. Yao, 姚雪彪）
　Address:Laboratory of Cellular Dynamics, University of Science and Technology of China, 

230026 Hefei, P. R. China
　Tel:86-551-63607141
　Fax:86-551-63606304
　E-mail:yaoxb@ustc.edu.cn



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　EDUCATION AND RESEARCH EXPERIENCE

1980-1984

B.S., Jiangxi College of Chinese Medicine, China

1991-1995

Ph.D., University of California-Berkeley, USA

1995-1997

Research Associate, University of California-San Diego, USA

1997-1999

Assistant Professor, University of Wisconsin-Madison, USA

2000-2003

Visiting Research Professor, University of California-Berkeley, USA

2003-2008

Georgia Cancer Coalition Eminent Scholar, USA

1999-

Professor of Cell Biology, University of Science & Technology of China

2008-

Director, Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, China

2016-

Head, Innovation Team on Centromere Dynamics & Plasticity Control, Natural Science Foundation of China


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　RESEARCH INTERESTS

1.

Chromosome segregation and stemness control

2.

Organoids architect and plasticity control

3.

Chemical biology of mitosis and metastasis

4.

Single molecule and super-resolution imaging


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　CURRENT RESEARCH PROJECTS

1.

Centromere Dynamics & Plasticity Control, Natural Science Foundation of China (2017-2012)

2.

Chemical biology of mitosis, Chinese Academy of Sciences (2016-2020)

3.

Single cell dynamics, Natural Science Foundation of China (2015-2019) 


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　REPRESENTATIVE PUBLICATIONS

1.

Ding, X; Yan, F; Yao, P; Yang, Z; Wan, W; Wang, X; Liu, J; Gao, X; Abrieu, A; Zhu, T; Zhang, J; Dou, Z; Yao, X. 2010. Probing CENP-E function in mitotic chromosome dynamics using small molecule inhibitor syntelin. Cell Research 20, 1386-1389.

2.

Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Xiang H, Gao F, Yu X, Liao J, Ward T, Xia P, Emenari C. Ding X, Thompson W, Ma K, Zhu J, Aikhionbare F, Dou K, Zhu J, Cheng S, and Yao X. 2011. Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Research 71, 1721-1730.

3.

Chen J, Yu F, Gong C, Yao D, Deng H, Wang F, Anderson K, Liu Q, McEwen M, Yao X*, Song E*. 2011. CCL18 from tumor associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19, 541-555; *correspondence.

4.

Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X*, Teng M*. 2012. The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nature Commun. 3, 782-791.

5.

Xia P, Wang Z, Liu X, Wu B, Ward T, Zhang L, Ding X, Gibbons G, Shi Y, Yao X. 2012. EB1 acetylation by PCAF ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A. 109, 16564-9.

6.

Zhao X, Wang D, Liu X, Liu L, Song Z, Zhu T, Adams G, Gao X, Tian R, Huang Y, Chen R, Wang F, Liu D, Yu X, Chen Y, Chen Z, Teng M, Ding X, Yao X. 2013. Phosphorylation of BAR domain of ACAP4 regulates membrane tubulation. Proc Natl Acad Sci USA. 110, 11023-8.

7.

Yao X, Li D, Pei G. 2013. In focus: Molecular and Cell Biology Research in China. Nat Rev Mol Cell Biol. 14, 600-606.

8.

Dou Z, Liu X, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*. 2015. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci USA.112, E4546-55

9.

Mo F, Zhuang X, Liu X*, Yao P, Qin B, Su Z, Zang J, Wang Z, Zhang J, Niu L, Hill DL, Fang G, Fu C, Yao X*. 2016. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nature Chem. Biol. 12, 226-232. *correspondence.


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