许 超


/uploads/image/2019/03/05/093f518d3398b3f31812d706cd73204d.jpg 姓  名: 许超
 地  址: 中国科学技术大学中区医学楼214
 邮  编:230026
 电  话:0551-63600061
 电  邮:Xuchaor@ustc.edu.cn
 主  页:https://biox.ustc.edu.cn/2018/1008/c692a341432/page.htm




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 教育与科研经历
  2000年中国科学技术大学生命科学学院获得本科学位
  2005年

中国科学技术大学生命科学学院获得博士学位

  2006-2008Mayo Clinic 博士后
  2009-2015University of Toronto 博士后
  2016至今中国科学技术大学生命科学学院 教授


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 目前研究方向

  运用X-射线晶体衍射以及核磁共振等工具,结合分子生物学,生物物理学以及化学生物学等手段,研究真核生物尤其是人体内和重大疾病(肿瘤和神经退行性疾病等)有关的生物大分子复合物结构。并通过化学小分子筛选辅助药物设计达到控制或者治疗疾病的目的,积极推进结构生物学向疾病治疗方向的转化。


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 代表性论文(*:通讯作者; #:共同第一作者)
  1.

#Guo, Q., #Liao, S.,#Kwiatkowski, S., Tomaka, W., Yu, H., Wu, G., Tu, X., Min, J., *Drozak, J., *Xu, C. Structural insights into SETD3-mediated histidine methylation on β-actin. eLife 8: e43676. (2019).

  2.

Liao, S., *Sun, H., *Xu, C. YTH Domain: A Family of N6-methyladenosine (m6A) Readers. Genomics, Proteomics & Bioinformatics. 16, 99-107. (2018).

  3.

*Xu, C., Ishikawa, H., Izumikawa, K., Li, L., He, H., Nobe, Y., Yamauchi, Y., Shahjee, M.H., Xian-Hui Wu, Yu, Y., Isobe, T., Takahashi, N., *Min, J. Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev. 30, 2376-2390. (2016).

  4.

#Chung, H., #Xu, C., #Fuchs, A.,Mund, A.,Lange, M.,Steage, H.,Schubert, T.,Bian,  C.,Dunkel, I., Eberharter, A., Regnard, C.,Klinker, H.,Meierhofer, D.,Cozzuto,L., Winterpacht, A., Di Croce, L., Min, J., Will, H., *Kinkley, S. PHF13 is a Molecular Reader and Transcriptional Co-Regulator of H3K4me2/3. eLife 5: e10607. (2016).

  5.

*#Xu, C., #Wang, X., #Liu, K., Roundtree, I., Tempel, W., Li, Y., Lu, Z., *He, C., *Min, J. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat. Chem. Biol. 10, 927-929. (2014). (Recommended by Faculty of 1000).

  6.

#Ni, Z., #Xu, C., Guo, X., Hunter, G., Kuznetsova, O., Tempel, W., Marcon, E., Zhong, G., Guo, H., Kuo, W., Li, J., Young, P., Olsen, J., Wan, C., Loppnau, P., Bakkouri, M., Senisterra, G., He, H., Huang, H., Sidhu, S., Emili, A., Murphy, S., Mosley, A., Arrowsmith, C., *Min, J., *Greenblatt, J.RPRD1A and RPRD1B Serve as RNA Polymerase II Carboxyl-Terminal Domain Scaffolds to Recruit RPAP2 for Serine 5 Dephosphorylation. Nat. Struct. Mol. Biol. 21, 686-695. (2014).

  7.

#Xu, Y., #Xu, C., #Kato, A., Tempel, W., Abreu, J.C., Bian, C.,Hu, Y., Hu, D., Zhao, B., Cerovina, T., Diao, J., Wu, F., He, H.H., Cui, Q., Clark, E., Ma, C., Barbara, A., Veenstra, G.J.C., Xu, G., Kaiser, U.B., Liu, X.S., Sugrue, S.P., He, X., *Min, J., *Kato, Y., *Shi, Y.G. Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for XenopusEye and Neural Development. Cell 151, 1200-1213. (2012).

  8.#Xu, C., #Jin, J., Bian, C., Lam, R., Tian, R., Weist, R., You, L., Nie, J., Bochkarev, A., Tempel, W., Tan, C., Wasney, G., Vedadi, M., Gish, G., Arrowsmith, C., Pawson, T., Yang, X., *Min, J. Sequence-specific Recognition of a PxLPxI/L Motif by the Ankyrin-repeat Tumbler Lock. Sci. Signal. 5, ra39. (2012). (cover article).
  9.#Bian, C., #Xu, C., #Ruan, J., #Lee, K., #Burke, T., Tempel, W., Barsyte, D., Li, J., Wu, M., Zhou, B., Fleharty, B.E., Paulson, A., Allali-Hassani, A., Zhou, J., Mer, G., Grant, P., *Workman, J.L., *Zang, J., *Min, J. Structural Basis of Sgf29 Tandem Tudor Domains Selectively Binding Methylated Histone H3K4 to Regulate Enzymatic Activity of the SAGA Complex. EMBO J. 30, 2849-2842. (2011).
  10.#Xu, C., #Bian, C., Lam, R., Dong, A. *Min, J. Structural Basis of Selective Binding of Nonmethylated CpG islands by the CXXC Domain of CFP1. Nat. Commun. 2: 227. (2011).
  11.

#Xu, C., #Bian, C., #Yang, W., Galka, M., Ouyang, H., Chen, C., Qiu, W., Liu, H., Jones, A., MacKenzie, F., Pan, P., *Li, S., *Wang, H., *Min, J. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc. Natl. Acad. Sci. 107, 19266-19271. (2010).


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