孙林峰


/uploads/image/2019/03/13/09ab3d97d00f34e6932c0b01c2b28824.jpg 姓  名: 孙林峰
 地  址: 安徽省合肥市中国科学技术大学生命科学楼
 邮  编:230027
 电  话:0551-63606932
 电  邮:sunlf17@ustc.edu.cn
 主  页:https://biox.ustc.edu.cn/2017/0527/c692a370262/page.htm




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 教育与科研经历
  2005-2009年清华大学生物科学与技术系,获学士学位
  2009-2014年

清华大学大学生命科学学院,获理学博士学位

  2014-2017年清华大学大学生命科学学院,博士后
  2017年至今中国科学技术大学生命科学学院,特任教授、博导


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 目前研究方向

  运用结构生物学(主要为冷冻电镜三维重构技术和X-射线晶体学)和生物化学等手段研究细胞中关键的、与重大疾病相关的膜蛋白分子机制,研究细胞内重要生物大分子机器的结构与功能。


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 代表性论文
  1.Liu X, Wang J#, Sun L#. (2018). Structure of the hyperosmolality-gated calcium permeable channel OSCA1.2. Nature Communications, 9(1):5060. (#, corresponding author)
  2.Sun L*, Zhou R*, Yang G*, Shi Y. (2017). Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by-secretase. Proceedings of the National Academy of Sciences of the United States of America, 114(4), E476-E485. (*, co-first author)
  3.Sun L, Li X, Shi Y. (2016). Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to-secretase. Current Opinion in Structural Biology, 37, 97–107.
  4.Sun L*, Zhao L*, Yang G*, Yan C*, Zhou R*, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y. (2015). Structural basis of human γ-secretase assembly. Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6003-6008. (*, co-first author)
  5.Madej MG*, Sun L*, Yan N, Kaback HR. (2014). Functional architecture of MFS D-glucose transporters. Proceedings of the National Academy of Sciences of the United States of America, 111(7), E719-727. (*, co-first author)
  6.Sun L*, Zeng X*, Yan C, Sun X, Gong X, Rao Y, Yan N. (2012). Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490(7420), 361-366. (*, co-first author)
  7.Dang S, Sun L*, Huang Y*, Lu F, Liu Y, Gong H, Wang J, Yan N. (2010). Structure of a fucose transporter in an outward-open conformation. Nature, 467(7316), 734-738. (*, co-author)


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