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肖卫华


/uploads/image/2019/06/27/63e8d4fa3a2858b4b176f4710958bcfe.png 姓  名: 肖卫华

医药生物技术系常务副主任;医药生物安徽省工程技术研究中心主任;安徽省生物工程学会理事长
 地  址:安徽省合肥市黄山路443号,230027

中国科学技术大学生命学院
 电  话:(0551) 3606294(办公室) ; (0551)3600536(实验室)
 电子邮件:xiaow@ustc.edu.cn
 主  页:http://lstt.ustc.edu.cn; http://gmp.ustc.edu




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 教育与科研经历

  1962年出生于吉林长春。1985年毕业于白求恩医科大学本科,2002年美国约翰•霍普金斯大学硕士,2008吉林大学医学博士。1985-1995年长春生物制品研究所应用分子生物助理研究员,1995年-1998年美国马里兰大学肿瘤研究中心博士后,1998-2004年美国国立肿瘤研究院研究员,2004年10月中国科学技术大学生命科学学院教授,信号转导与基因调控实验室课题负责人;中科大医药生物技术系常务副主任;中科大生物医药工程技术研究中心主任;中国抗癌协会肿瘤生物治疗分会副主任委员;安徽省生物工程学会理事长。主持国家自然基金7项;973课题组长、骨干成员3项;国家新药创制重大专项负责人、骨干成员各1项;省部级重大、重点项目10余项。发表SCI收录研究论文40余篇;申请专利16项,获授权8项。


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主要研究兴趣
  1.分子肿瘤和分子免疫学

肿瘤细胞复杂信号网络异常及基因调控机制和作用

炎症与肿瘤的作用与机制
  2.生物技术及药物的研究开发

生物技术药物及免疫治疗技术和产品的研发


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 代表文章
  1.Jia, H., Y. Guo, X. Song, C. Shao, J. Wu, J. Ma, M. Shi, Y. Miao, R. Li, D. Wang, Z. Tian, and W. Xiao. Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-alpha/Fc fusion proteins expressed in Pichia pastoris. Microb Cell Fact. 2016. 15: 209.
  2.Wang, D., J. Y. Chen, R. Li, G. L. Wu, Z. M. Sun, Z. T. Wang, Z. M. Zhai, F. Fang, Y. G. Guo, Y. J. Zhong, M. Jiang, H. Xu, M. H. Chen, G. D. Shen, J. Sun, B. L. Yan, C. D. Yu, Z. G. Tian, and W. H. Xiao. PAX5 interacts with RIP2 to promote NF-kappaκB activation and drug-resistance in B-lymphoproliferative disorders. J. Cell Sci. 2016. 129: 2261-2272.
  3.Guo Y, Wu J, Jia H, Chen W, Shao C, Zhao L, Ma J, Li R, Zhong Y, Fang F, Wang D, Sun J, Qian F, Dai X, Zhang G, Tian Z, Xiaoyi Li B, Xiao W. Balancing the Expression and Production of a Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate. Sci Rep. 2015 Jul 6;5:11730.
  4.Zhong Y, Yang L, Guo Y, Fang F, Wang D, Li R, Jiang M, Kang W, Ma J, Sun J, Xiao W. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10. Microb Cell Fact. 2014 Nov 26;13:163.
  5.Ren Z, Kang W, Wang L, Sun B, Ma J, Zheng C, Sun J, Tian Z, Yang X, Xiao W. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-κB modulation. Mol Cancer. 2014 Apr 17;13:84.
  6.Guo Y, Li R, Song X, Zhong Y, Wang C, Jia H, Wu L, Wang D, Fang F, Ma J, Kang W, Sun J, Tian Z, Xiao W. The expression and characterization of functionally active soluble CD83 by Pichia pastoris using high-density fermentation. PLoS One. 2014 Feb 20;9(2):e89264
  7.Sun H, Sun C, Xiao W. Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine. 2014 Jan;65(1):33-41
  8.Cheng M, Chen Y, Xiao W, Sun R, Tian Z. NK cell-based immunotherapy for malignant diseases. Cell Mol Immunol. 2013 May;10(3):230-52.
  9.Sun H, Sun C, Tian Z, Xiao W. NK cells in immunotolerant organs. Cell Mol Immunol. 2013 May;10(3):202-12. Review.
  10.Ma Y, Cheng Q, Ren Z, Xu L, Zhao Y, Sun J, Hu S, Xiao W. Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett. 2012 Apr 28;317(2):150-6.
  11.Fang F, Wang Y, Li R, Zhao Y, Guo Y, Jiang M, Sun J, Ma Y, Ren Z, Tian Z, Wei F, Yang D, Xiao W. Transcription factor E2F1 suppresses dendritic cell maturation. J Immunol. 2010; 184(11): 6084-91.
  12.Ma J, Ren Z, Ma Y, Xu L, Zhao Y, Zheng C, Fang Y, Xue T, Sun B, Xiao W. Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8 mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. J Biol Chem. 2009; 284(50): 34600-6.
  13.Zheng C, Ren Z, Wang H, Zhang W, Kalvakolanu DV, Tian Z, Xiao W. E2F1 Induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res. 2009; 69(6): 2324-31.
  14.Xiao, W., Hodge, D. R., Wang, L. H., Yang, X. Y., Zhang, X., and Farrar, W. L. Nuclear Factors NF-kB and c-Jun cooperatively Regulate the IL-6 Biosyntheses in Autocrine Human Multiple Myeloma Cells. Cancer Biol. & Ther. 2004; 3(10):1007-1017.
  15.Xiao, W., Wang, L., Yang, X., Chen, T., Hodge, D., Johnson, P. F., and Farrar, W. CCAAT/enhancer-binding protein-b mediates interferon-gamma-induced p48 (ISGF3-g ) gene transcription in human monocytic cells. J.Biol.Chem. 2001; 276: 23275-23281.
  16.Weihua, X., Ramanujam, S., Lindner, D. J., Kudaravalli, R. D., Freund, R., and Kalvakolanu, D. V. The polyoma virus T antigen interferes with interferon-inducible gene expression. PNAS 1998; 95:1085-1090.
  17.Weihua, X., Kolla, V., and Kalvakolanu, D. V. Interferon-g-induced transcription of the murine ISGF3-γ (p48) gene is mediated by novel factors. PNAS 1997; 94: 103-108.
  18.Weihua, X., Lindner, D. J., and Kalvakolanu, D. V. The interferon-inducible murine p48 (ISGF3-g) gene is regulated by protooncogene c-myc. PNAS 1997; 94: 7227-7232


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