李 海
 | 姓 名: | 李海 |
地 址: | 中国科学技术大学西区生科大楼K717室 | |
邮 编: | 230026 | |
电 话: | 0551-63600497 | |
邮 箱: | hai_li@ustc.edu.cn | |
主 页: | https://biomed.ustc.edu.cn/2022/1219/c31898a588862/page.htm |
| 教育与科研经历 |
工作经历 | ||
2022.12 - 至今 | 中国科学技术大学 | 特任教授 |
2017.10 - 2022.11 | 瑞士伯尔尼大学小岛医院 | 导师Andrew Macpherson 高级研究助理 |
2011.09 - 2017.10 | 瑞士伯尔尼大学 | 导师Andrew Macpherson 博士后 |
学习经历 | ||
2005.09 - 2011.07 | 上海生化所 | 导师刘小龙 博士 |
2001.09 - 2005.07 | 山东师范大学 | 学士 |
| 目前研究方向 |
主要从事肠道微生物共生方向及其对宿主获得性免疫功能的研究。研究内容为运用简化的单菌定殖模型对肠道共生中的微生物和宿主获得性免疫发生、成熟及功能行使之间的相互关系等问题的研究和阐释。 |
| 代表性论文 |
1. | Li H*, Limenitakis JP*, Greiff V, Yilmaz B, Schären O, Urbaniak C, Zünd M, Melissa L, Young I, Rupp S, Heikenwälder M, McCoy KD, Hapfelmeier S, Ganal-Vonarburg S*, Macpherson AJ*. Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature, 2020, 584, pages274–278 (*equal contribution) |
2. | Uchimura Y*, Fuhrer T*, Li H*,Lawson MA,Zimmermann M,Yilmaz B, Zindel J,Ronchi F, Sorribas M, Hapfelmeier S, Ganal-Vonarburg SC, Gomez de Agüero M, McCoy KD, Sauer U, Macpherson AJ. Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response. Immunity, 2018 Sep 18;49(3):545-559.e5. (*equal contribution) |
3. | Li H*, Limenitakis JP*, Fuhrer T, Geuking MB,Lawson MA,Wyss M, Brugiroux S,Keller I, Macpherson JA, Rupp S, Stolp B, Stecher B, Stein JV, Sauer U, McCoy KD, Macpherson AJ. The outer mucus layer hosts a distinct intestinal microbial niche. Nat. Comm., 2015, 6 (1), 1-13 (*equal contribution) |
4. | Li H, Limenitakis JP, Ganal S, Macpherson AJ. Penetrability of the inner mucus layer: who is out there? EMBO Reports, 2015 ,16 (2), 127-129 (research commentary) |
5. | Perruzza L, Strati F, Raneri M, Li H, Gargari G, Rezzonico-Jost T, Palatella M, Kwee I, Morone D, Seehusen F, Sonego P, Donati C, Franceschi P, Macpherson AJ, Guglielmetti S, Greiff V, Grassi F. Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis. Cell reports., 2022, 40 (3), 111112 |
6. | Yilmaz B, Mooser C, Keller I, Li H, Zimmermann J, Bosshard L, Fuhrer T, Gomez de Agüero M, Fernandez Trigo N, Tschanz-Lischer H, Limenitakis JP, Hardt WD, McCoy KD, Stecher B, Excoffier L, Sauer U, Ganal-Vonarburg SC, Macpherson AJ. Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice. Cell host & microbe, 2021, 29 (4), 650-663. e9 |
7. | Singh S, Thompson JA, Yilmaz B, Li H, Weis S, Sobral D, Truglio M, Aires da Silva F, Sandra Aguiar S, Carlos AR, Rebelo S, Cardoso S, Gjini E, Nuñez G, Soares MP. Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. Cell host & microbe, 2021, 29 (3), 347-361. e12 |
8. | Sanchez-Taltavull D, Castelo-Szekely V, Murugan S, Hamley JID, Rollenske R , Ganal-Vonarburg SC, Büchi I, Keogh A, Li H, Salm L, Spari D, Yilmaz B, Zimmermann J, Gerfin M, Roldan E, Beldi G, UVCM-COVID researchers. Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures. PloS one, 2021, 16 (11), e0258700 |
9. | Pfister SP, Schären OP, Beldi L, Printz A, Notter MD, Mukherjee M, Li H, Limenitakis JP, Werren JP, Tandon D, Cuenca M, Hagemann S, Uster SS, Terrazos MA, Gomez de Agüero M, Schürch CM, Coelho FM, Curtiss R 3rd, Slack E, Balmer ML, Hapfelmeier S. Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity. Nat Comm., 2020 Apr 24;11(1):1978 |
10. | Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T,Saveljeva S,Gensollen T,Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science, 2019 Mar 1;363(6430):993-998 |
11. | Sorribas M, Jakob MO, Yilmaz B, Li H, Stutz D, Noser Y, de Gottardi A, Moghadamrad S, Hassan M, Albillos A, Francés R, Juanola O, Spadoni I, Rescigno M, Wiest R. FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis. J Hepatol., 2019 Dec;71(6):1126-1140 |
12. | Yilmaz B & Li H. Gut Microbiota and Iron: The Crucial Actors in Health and Disease. Pharmaceuticals. 2018 Oct 5;11(4):98. (Review) |
13. | Gomez de Agüero M, Ganal-Vonarburg SC, Fuhrer T, Rupp S, Uchimura Y, Li H, Steinert A, Heikenwalder M, Hapfelmeier S, Sauer U, McCoy KD, Macpherson AJ. The maternal microbiota drives early postnatal innate immune development. Science. 2016 |
14. | Brasseit J, Althaus-Steiner E, Faderl M, Dickgreber N, Saurer L, Genitsch V, Dolowschiak T, Li H, Finke D, Hardt WD, McCoy KD, Macpherson AJ, Corazza N, Noti M, Mueller C. CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis. Mucosal Immunol. 2016 |
15. | Cao Y*, Li H*, Liu H, Sun Y, Chen X, Zheng C, Ji H and Liu X. The serine/ threonine kinase LKB1 regulates thymocyte positive selection and TCR signal transduction. EMBO J. 2011 (*equal contribution) |
16. | Cao Y*, Li H*, Liu H, Zheng C, Ji H and Liu X. The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression. Cell Research. 2010 (*equal contribution) |
17. | Cao Y*, Li H*, Sun Y, Chen X, Liu H, Gao X and Liu X. Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression. EJI. 2010 (*equal contribution) |
18. | Balmer ML, Schürch CM, Saito Y, Geuking MB, Li H, Cuenca M, Kovtonyuk LV, McCoy KD, Hapfelmeier S, Ochsenbein AF, Manz MG, Slack E, Macpherson AJ. Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. J Immunol. 2014 |
19. | Zhang Y, Li H, Wang X, Gao X, Liu X. Regulation of T cell development and activation by creatine kinase B. PLoS One, 2010 |
20. | Zhang Y, Yang Z, Cao Y, Zhang S, Li H, Huang Y, Ding Y and Liu X. The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells. Biochemistry Journal, 2009 |
