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朱 书


/uploads/image/2019/07/22/952d25e89e7afc1e801cef00844e0d15.png 姓  名: 朱 书
 地  址:安徽省合肥市蜀山区黄山路443号,中国科学技术大学生命科学学院
 电  话:0551-63600620
 电子邮箱:zhushu@ustc.edu.cn




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 教育与科研经历
  2002年-2006年中国科学技术大学生命科学学院,获学士学位
  2006年-2012年

上海生命科学研究院健康科学研究所,获细胞生物学博士学位

  2012年-2017年美国耶鲁大学医学院免疫学系,博士后
  2017年-至今中国科学技术大学生命科学学院,教授博导


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 获奖情况

2006年郭沫若奖学金

2011年中科院院长优秀奖

2011年强生亚洲优秀研究生论文奖

2012年中科院院长特别奖

2012年吴瑞奖学金

2012年中科院百篇优博论文

2014年Helen-Hay Whitney-HHMI 奖学金


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 目前研究方向

  肠道作为人体最大的粘膜免疫器官,聚集了远超过人体细胞数目的微生物,当前的研究显示这些微生物不仅和人体保持共生关系,为人体正常生理过程比如营养物质的代谢和吸收提供帮助,在特定情况下也会对人类疾病造成负面的影响,比如说促进免疫性疾病(IBD),代谢性疾病(肥胖),神经性疾病(抑郁),甚至肿瘤。另外大量肠道微生物的存在导致肠道共同进化形成拥有由功能各异的上皮细胞组成的黏膜屏障,以及由全身一半以上的免疫细胞组成的复杂精密的免疫系统。实验室的兴趣在于利用小鼠模型来研究在正常情况下,肠道黏膜屏障如何隔绝微生物,免疫细胞和上皮细胞如何识别微生物,以及肠道T细胞如何介导和调节针对微生物免疫反应。另外由于遗传,感染,饮食等造成的肠道微生态失调和人类疾病紧密相关,实验室对于肠道微生态失调是如何形成,以及失调的微生态是如何影响肠道免疫反应和人类疾病也非常感兴趣。以期通过靶向宿主免疫反应,或者直接靶向微生态,来实现对于人类疾病比如感染,免疫性疾病和肿瘤的干预。实验室将主要利用擅长的多种小鼠模型(KI/KO, reporter, 疾病模型, 人源化),CRISPR筛选和新一代测序来研究:

1.肠道黏膜屏障,先天免疫识别,感染和炎症;

2.T细胞介导的免疫反应,自身免疫和肿瘤;

3.疾病状态下肠道微生态谱(细菌和病毒),微生态失调的形成机制以及微生态失调对免疫系统和疾病的影响。


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 代表性论文
  Innate immune recognition/Infection and Inflammation
  1.Zhu S*, Ding S*, Wang P, Wang G, Lei X, Palm N, Pan W, Zheng Y, Feng N, Lu J, Shan L, Abraham C, Fikrig E, Greenberg H, Flavell R. Nlrp9b recognizes and restricts rotavirus infection in intestinal epithelial cells. 2017. Nature. doi:10.1038/nature22967.(Comment in Nature, doi:10.1038/nature23090, Research highlight in Cell Research, doi: 10.1038/cr.2017.93 *co-first author).
  2.Wang P*, Zhu S*, Yang L, Cui S, Pan W, Jackson CelR, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R#, Fikrig E#. 2015. Nlrp6 regulates intestinal antiviral innate immunity. Science. 10.1126/science.aab3145. (Comment in Science Signaling (2015), *co-first author, #co-corresponding author)
  3.Zhu S, Li HB, Flavell RA. 2014. Resemble and Inhibit: when RLR meets TGF-b. Molecular Cell. Dec 18;56(6):719-20. doi:10.1016/j.molcel.2014.12.010
  4.Zhu S, Jackson R, Flavell RA. 2014. The lock-washer: a reconciliation of the RIG-I activation models. Cell Research.10.1038/cr.2014.5
  5.Shu Zhu, Geng Wang, Xuqiu Lei, Richard A. Flavell. 2016. Mex3B, a coreceptor to present dsRNA to TLR3. Cell Research. 26(4):391-2. doi: 10.1038/cr.2016.29.
  6.Marcel R. de Zoete*, Noah W. Palm*, Shu Zhu*, Richard A. Flavell. 2014. Inflammasomes. Cold Spring Haber Perspectives in Biology. (*co-first author)
  7.Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. 2016. The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science. 2016 Nov 11;354(6313):765-768.
  8.Yao Y., Y. Wang, F. Chen, Y. Huang, S. Zhu, Q. Leng, H. Wang, Y. Shi, Y. Qian. 2012. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogen. Cell Research. 04/2012.
  T cells and cytokine /Autoimmune and immune-oncology
  1.Li, H.*, J. Tong*, S. Zhu*, P. Batista, J.Zhao, W. Bailis, Y. Yang, G. Wang, Y. Chen, Y. Kluger, Howard Y. Chang, Zhinan Yin, Richard A. Flavell. 2017. m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway pathway. Nature. In press.(*co-first author)
  2.Zhu, S.*, W. Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y. Qian. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nature Medicine. 18: 1077-1086. DOI 10.1038/nm.2815(Comment in Nature Reviews Immunology (2012) 12, 474-475; Comment in Nature Medicine (2012) 18, 1009–1010; Evaluated by Faculty of 1000 Biology. *co-first author).
  3.Zhu, S., W. Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med. 207:2647-2662.(Research highlight in Nature Medicine (2011) 17:52; Research highlight in Nature Immunology (2011) 12:19; Evaluated by Faculty of 1000 Biology).
  4.Pan W*, Zhu S*, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y,.. Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley J, Flavell R, Yao Y and Shen N. 2015. MiR-125a targets effector programs to stabilize Treg mediated immune homeostasis and controls autoimmunity. Nature Communication. DOI: 10.1038/ncomms8096. (*co-first author)
  5.Pan, W*, S. Zhu*, M. Yuan, H. Cui, L. Wang, X. Luo, J. Li, H. Zhou, Y. Tang, and N. Shen. 2010. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol. 184:6773-6781.(*co-first author; 331 citations)
  6.Zhu S*, Pan W, Qian Y*. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. (*co-corresponding author; Invited review)
  7.Zhu, S. & Qian, Y. 2012. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci (Lond) 122, 487-511. (Invited review)
  8.Song, X., S. Zhu, P. Shi, Y. Liu, Y. Shi, S.D. Levin, and Y. Qian. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nature Immunology. 12:1151-8.
  9.Shi, P., S. Zhu, Y. Lin, Y. Liu, Z. Chen, Y. Shi, and Y. Qian. 2011. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1. Science Signaling. 4:ra73.
  10.Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y. 2015. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity. doi:10.1016/j.immuni.2015.06.024
  11.Pan W, Zhu S, K Qu, K Meeth, J Cheng, H Ma, Y Liao, X Wen, C Roden, Z Tobiasova, Z Wei, J Zhao, J Liu, J Zheng, B Guo, M Bosenberg, R Flavell, J Lu. 2017. Tet2 sustains the immunosuppressive function of myeloid cells and promotes melanoma growth. Immunity. In press.
  12.Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. 2014. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 40 (1), 140-152
  13.Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA. 2016. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood. doi: 10.1182/blood-2016-04-709584.
  14.Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J. 2016. A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional Mapping of Noncoding Regions. Nature Communication. 7:11178. doi: 10.1038/ncomms11178.


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