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金腾川


/uploads/image/2019/04/02/f37d4ebae2b0b48c23ba1703b6a61928.png 姓  名: 金腾川
 地  址: 中区医学楼303
 邮  编:230027
 电  话:0551-63600720
 电  邮:Jint@ustc.edu.cn
 主  页:Tjlab.ustc.edu.cn




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 教育与科研经历
  1998 - 2003中国科学技术大学,生物学理学学士
  1998 - 2003

中国科学技术大学,工商管理学士

  2003 - 2008美国伊利诺伊理工大学,分子生物化学和生物物理学博士
  2008 - 2012博士后, 美国国立卫生研究院
  2012 - 2014研究员(Research Fellow), 美国国立卫生研究院
  2015 - 目前特任研究员、博导,中国科学技术大学


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 目前研究方向
  1.天然免疫受体的结构生物学
  2.炎症小体的结构与功能
  3.病原体与宿主相互作用的分子机制
  4.蛋白质工程与蛋白药物


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 代表性论文
  1.Jin T*,, Brefo. E, Fan W, Zeng W, Li Y, Zhang YZ, Palmer M (2018). Crystal structure of the Streptococcus agalactiae CAMP factor provides insights into its membrane-permeabilizing activity. J Biol Chem 293(30):11867-11877.
  2.Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T* (2018). Functional and Structural Characterization of Zebrafish ASC. FEBS J 285(14):2691-2707.
  3.Jin T*, Wang C, Zhang CY, Wang Y, Chen YW, Guo F, Howard A, Cao MJ, Fu TJ, McHugh TH, Zhang YZ* (2017) Crystal Structure of Cocosin, A Potential Food Allergen from Coconut 
(Cocos nucifera). J Agric Food Chem 65(34): 7560-7568.
  4.Cao X#, Li YJ#*, Jin X, Li YL, Guo F, Jin T* (2017). Molecular Mechanism of Divalent-Metal-Induced Activation of NS3 Helicase and Insights into Zika Virus Inhibitor Design. Nucleic Acids Res 44(21): 10505-10514.
  5.Chuenchor W#, Jin T#, Ravilious G, Xiao TS* (2014). Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization. Curr Opin Immunol 26:14-20. (#co-first author, invited review).
  6.Sirois CM#, Jin T#, Miller AL, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Brewah Y, Tian J, Chang C, Schowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS*, Latz E * (2013) RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. J Exp Med 210: 2447-2463. (#co-first author). Highlighted in the November 2013 issue of Nature Structural & Molecular Biology.
  7.Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam V, Hornung V, Johnstone RW, Latz E, Bowie AG, Fitzgerald KA, Xiao TS (2012) Structures of The HIN domain:DNA complexes reveal ligand binding and activation mechanisms of The AIM2 inflammasome and IFI16. Immunity 36(4): 561-571


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