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张隆华

	姓　　名:	张隆华
	地　　址:	中国科学技术大学西校区，生命科学学院518房间
	邮　　编:	230027
	传　　真:	86-551-63607001
	电　　邮:	zlhustc@ustc.edu.cn

　教育与科研经历

1996 - 2000	中国科学技术大学生命科学学院本科
2000 - 2006	中国科学技术大学生命科学学院研究生
2006 - 2010	美国马里兰大学医学院博士后
2011 - present	中国科学技术大学生命科学学院副教授

　目前研究方向

1.	配体、辅助亚基调控离子通道功能的结构基础。
2.	通过荧光和其他生物物理方法研究膜蛋白动态构象变化。

　代表性论文

1.	Zhang M, Wen M, Xiong Y, *Zhang L()*, Tian C(). In cell measurement of fluorescent lifetime imaging microscopy revealed C-terminal conformation changes of Ferroportin upon addition of Mn²⁺, *Chinese Chem Lett*, 2018, 29: 1509-1512.
2.	Yu M, Liu S, Sun P, Pan H, Tian C(), Zhang L(). Peptide Toxins and small-molecule blockers of BK channels, Acta Pharmacol Sin**, 2016, 37(1):56-66.
3.	Liu S, Lv P, Li D, Guo X, Zhang B, Yu M, Li D, Xiong Y, *Zhang L()*, Tian C(). K(+) preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine, *Chem Commun (Camb)*, 2015, 51(88):15971-15974.
4.	Sun P, Wu F, Wen M, Yang X, Wang C, Li Y, He S, *Zhang L()*, Zhang Y(), Tian C(). A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit, Sci Rep*, 2015, 5: 13399.
5.	Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, *Zhang L()*, Tian C(). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells, *Chem Commun (Camb)*, 2015, 51(38):8153-8156.
6.	Yu L, Wang W, Ling S, He Y, Xiao L, Wu K, *Zhang L()*, Tian C(). Distance measurement between two flexible sites in proteins in high viscosity medium at physiological temperature using continuous wave EPR, *Protein Cell*, 2014, 5(5):334-337.
7.	Zhang L, Alger BE(). Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome, J Neurosci*, 2010, 30(16):5724-9.
8.	Edward DA, Zhang L, Alger BE(). Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus, Proc Natl Acad Sci U S A*, 2008, 105(23):8142-8147.
9.	Zhang L, Gong N, Fei D, Xu L(), XU T(). Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. *Neuropsychopharmacology*, 2008, 33(3):701-711.

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