张隆华


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姓  名:

张隆华

地  址:

中国科学技术大学西校区,生命科学学院518房间

邮  编:

230027

传  真:

86-551-63607001

电  邮:

zlhustc@ustc.edu.cn




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 教育与科研经历

1996 - 2000

中国科学技术大学 生命科学学院 本科

2000 - 2006

中国科学技术大学 生命科学学院 研究生

2006 - 2010

美国马里兰大学 医学院 博士后

2011 - present

中国科学技术大学 生命科学学院 副教授


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 目前研究方向

1.

配体、辅助亚基调控离子通道功能的结构基础。

2.

通过荧光和其他生物物理方法研究膜蛋白动态构象变化。


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 代表性论文

1.

Zhang M, Wen M, Xiong Y, Zhang L(*), Tian C(*). In cell measurement of fluorescent lifetime imaging microscopy revealed C-terminal conformation changes of Ferroportin upon addition of Mn2+, Chinese Chem Lett, 2018, 29: 1509-1512.

2.

Yu M, Liu S, Sun P, Pan H, Tian C(*), Zhang L(*). Peptide Toxins and small-molecule blockers of BK channels, Acta Pharmacol Sin, 2016, 37(1):56-66.

3.

Liu S, Lv P, Li D, Guo X, Zhang B, Yu M, Li D, Xiong Y, Zhang L(*), Tian C(*). K(+) preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine, Chem Commun (Camb), 2015, 51(88):15971-15974.

4.

Sun P, Wu F, Wen M, Yang X, Wang C, Li Y, He S, Zhang L(*), Zhang Y(*), Tian C(*). A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit, Sci Rep, 2015, 5: 13399.

5.

Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L(*), Tian C(*). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells, Chem Commun (Camb), 2015, 51(38):8153-8156.

6.

Yu L, Wang W, Ling S, He Y, Xiao L, Wu K, Zhang L(*), Tian C(*). Distance measurement between two flexible sites in proteins in high viscosity medium at physiological temperature using continuous wave EPR, Protein Cell, 2014, 5(5):334-337.

7.

Zhang L, Alger BE(*). Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome, J Neurosci, 2010, 30(16):5724-9.

8.

Edward DA, Zhang L, Alger BE(*). Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus, Proc Natl Acad Sci U S A, 2008, 105(23):8142-8147.

9.

Zhang L, Gong N, Fei D, Xu L(*), XU T(*). Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology, 2008, 33(3):701-711.


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