窦 震


/uploads/image/2019/03/18/297636bc52a33b5d130a5554ad767e01.jpg Name: Dou Zhen (窦震)
 Born: November 3, 1976, Anhui, P. R. China
 Address:Room 545, Biology Building, University of Science and Technology of China, 230027 Hefei, P. R. China
 Tel:86-551-63607141
 Fax:86-551-63607141
 E-mail:douzhen@ustc.edu.cn




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 Education and Research Experience
  1994.09-1998.07

Department of Biology, Anhui University

Major: Microbiology, Degree: Bachelor of Science 

  1998.09-2004.11

School of Life Sciences, USTC 

Major: Molecular and Cellular Biology, Degree: Ph.D.

  2004.12-2007.04

School of Life Sciences, USTC

Post-doctoral researcher 

  2005.05-2005.12

Morehouse School of Medicine, USA

Visiting scholar 

  2007.05-2009.10

Max-Planck Institute of Biochemistry, Germany

Post-doctoral researcher 

  2010.01-present

Hefei National Laboratary for Physical Science at the micro-scale,

University of Science and Technology of China, associated professor 


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 Honors

Scholarship to attend 5th Doctoral students conference of APRU (Association of Pacific Rim Universities) (2004, Sydney)

Postdoctoral researcher fellowship from Max-Planck Society, Germany (2007-2009)

Excellent research paper award of School of Life Sciences, USTC. (2015)


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 Professional Membership

Member of the American Society for Cell Biology

Member of the Chinese Society of Cell Biology


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 Research Interests

Kinetochore and Mitosis; Mitotic kinases; Ubiquitin-proteasome system in cell cycle control;

Genome instability and cancer.


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 Representative Publications
  1.Dou Z#, Liu X#, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*. 2015. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci U S A. 112(33): E4546-55.
  2.Wang X, Yu H, Xu L, Zhu T, Zheng F, Fu C, Wang Z, Dou Z*. 2014. Dynamic autophosphorylation of Mps1 kinase is required for faithful mitotic progression. PLOS ONE. 9 (9): e0104723.
  3.Zhu T#, Dou Z#, Qin B, Jin C, Wang X, Xu L, Wang Z, Zhu L, Liu F, Gao X, Ke Y, Wang Z, Aikhionbare F, Fu C, Ding X, Yao X*. 2013. Phosphorylation of Microtubule-binding Protein Hec1 by Mitotic Kinase Aurora B Specifies Spindle Checkpoint Kinase Mps1 Signaling at the Kinetochore. J. Biol. Chem. 288: 36149-36159. (# equal contribution)
  4.Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S*, Bolanos-Garcia VM*. 2012. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem J. 448: 321-8.
  5.Dou Z, von Schubert C, Körner R, Santamaria A, Elowe S and Nigg EA*. 2011. Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1. PLoS ONE. 6(4):e18793.
  6.Hua S, Wang Z, Jiang K, Huang Y, Ward T, Zhao L, Dou Z*, Yao X*. 2011. CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment. J Biol Chem. 286: 1627-38. (* corresponding author)
  7.Zhao L, Chu J, Yuan K, Liu J, Yan F, Miao Y, Shaw A, Jin C, Dou Z*, Yao X*. 2010. Dimerization of CPAP orchestrates centrosome cohesion plasticity. J Biol. Chem. 285: 2488-97. (* corresponding author)
  8.Elowe S, Dulla K, Uldschmid A, Li X, Dou Z, Nigg EA. 2010. Uncoupling BubR1 spindle checkpoint and chromosome congression functions. J Cell Sci. 123: 84-94.


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