张 智



Zhi Zhang (张智)


Department of Biophysics and Neurobiology

University of Science and Technology of China 

443 Huangshan Street, Hefei City, Anhui 230027, P.R.China


+86 551-6360-2715





11/2012- present

Professor, University of Science and Technology of China


Postdoctoral Fellow, Departments of Pain Medicine and Anesthesiology, University of Texas-MD Anderson Cancer Center


Ph.D., Department of Neurobiology, University of Science and Technology of China


B.S., Department of Biochemistry, Anhui University



Our research is focused on understanding the neurobiological mechanisms of comorbidity of pain and emotional disorders, with an emphasis on the neural circuits in development of negative emotion in chronic pain states. Additionally, we are also interested in how glial cells regulate neuronal circuit adaptation and its roles for pain. We are currently using a multidisciplinary approach that includes viral tracing, electrophysiological recording (in vivo and in vitro), calcium imaging, and molecular biological techniques, with the goal of elucidating how chronic pain modifies synaptic and circuit function through brain gene activity changes, in turn influences emotional behaviors.







Weiwei Yin†, Lisheng Mei†, Tingting Sun, Yuping Wang, Jie Li, Changmao Chen, Zahra Farzinpour, Yu Mao, Wenjuan Tao, Juan Li, Wen Xie and Zhi Zhang(张智)*, A central amygdala–ventrolateral periaqueductal gray matter pathway for pain in a mouse model of depression-like behavior, Anesthesiology, 2020 Jan 27.


Yan Jin†, Qian Meng†, Lisheng Mei, Wenjie Zhou, Xia Zhu, Yu Mao, Wen Xie, Xulai Zhang, Min-Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Xiangyao Li and Zhi Zhang(张智)*, A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain, Pain, 2020 Feb;161(2):416-428.


Xia Zhu†, Wenjie Zhou†, Yan Jin, Haodi Tang, Peng Cao, Yu Mao, Wen Xie, Xulai Zhang, Fei Zhao, Min-Hua Luo, Haitao Wang, Jie Li, Wenjuan Tao, Zahra Farzinpour, Likui Wang, Xiangyao Li, Juan Li, Zheng-QuanTang, Chenhua Zhou, Zhizhong Z. Pan* and Zhi Zhang(张智)*, A central amygdala input to the parafascicular nucleus controls comorbid pain in depression, Cell Reports, 2019 Dec; 29(12): 3847-3858.


Wenjie Zhou†, Yan Jin†, Qian Meng†, Xia Zhu†, Tongjian Bai, Yanghua Tian, Yu Mao, Likui Wang, Wen Xie, Hui Zhong, Na Zhang, Min-Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Ben-Sheng Qiu, Jiang-Ning Zhou, Xiangyao Li, Han Xu, Kai Wang, Xiaochu Zhang, Yong Liu, Gal Richter-Levin, Lin Xu and Zhi Zhang(张智)*, A neural circuit for comorbid depressive symptoms in chronic pain, Nature Neuroscience, 2019 Oct; 22(10):1649-1658.


Tingting Sun†, Zihua Song†, Yanghua Tian, Wenbo Tian, Chunyan Zhu, Yu Mao, Wen Xie, Hui Zhong, Fei Zhao, Min-Hua Luo, Jiang-Ning Zhou, Kai Wang* and Zhi Zhang(张智)*, Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior, PNAS, 2019 Feb 26;116(9): 3799-3804.


Haitao Wang†, Jiahui Chen†, Xiaotong Xu, Wen-Jian Sun, Xi Chen, Fei Zhao, Min-Hua Luo, Chunhua Liu, Yiping Guo, Wen Xie, Hui Zhong, Tongjian Bai, Yanghua Tian, Yu Mao, Chonghuan Ye, Wenjuan Tao, Jie Li, Zahra Farzinpour, Juan Li, Jiang-Ning Zhou, Kai Wang, Jufang He, Lin Chen* and Zhi Zhang(张智)*, Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior, PLoS Biology, 2019 Aug 30; 17(8): e3000417.


Tao Wenjuan, Chen Quan, Zhou Wenjie, Wang Yuping, Wang Lu and Zhang Zhi(张智)*, Persistent inflammation-induced up-regulation of brain-derived neurotrophic factor (BDNF) promotes synaptic delivery of α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor GluA1 subunits in descending pain modulatory circuits, Journal of Biological Chemistry, 2014 Aug 8; 289(32): 22196-204.


Zhi Zhang(张智)*, Wenjuan Tao, Yuan-Yuan Hou, Wei Wang1, Yun-Gang Lu and Zhizhong Z Pan*, Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function, Neuropsychopharmacology, 2014 Aug; 39(9): 2263-71.


Zhi Zhang(张智), Wenjuan Tao, Yuan-Yuan Hou, Wei Wang, Paul J. Kenny and Zhizhong Z. Pan*, MeCP2 repression of G9a in regulation of pain and morphine reward, Journal of Neuroscience, 2014 Jul 2; 34(27): 9076-87.


Zhi Zhang(张智), You-Qing Cai, Fang Zou, Bihua Bie and Zhizhong Z Pan*, Epigenetic suppression of GAD65 expression mediates persistent pain. Nature Medicine, 2011 Oct 9; 17(11): 1448-55. 7. Highlighted by Nature Reviews Drug Discovery (2011 Nov 18;10(12):900).


Zhi Zhang(张智)and Zhizhong Z Pan*, Synaptic mechanism for functional synergism between delta and mu-opioid receptors, Journal of Neuroscience, 2010 Mar 31; 30(13): 4735-45. Highlighted by Nature Reviews Neuroscience (2010 May 12; 11:374-375).


Zhi Zhang(张智), Neng Gong, Wei Wang, Lin Xu and Tian-Le Xu*, Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval, Cerebral Cortex, 2008 Oct; 18(10): 2391-401.