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刘　强


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姓　　名:

刘　强

地　　址:

安徽省合肥市黄山路443号

邮　　编:

230027

电　　话:

0551-63601179

电　　邮:

Liuq2012@ustc.edu.cn



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　教育与科研经历

1996–2000

山东大学，学士， 生物化学与分子生物学专业

2000-2005

中科院生物物理所，博士，生物物理学

2005-2010

华盛顿大学医学院，博后

2010-2011

华盛顿大学医学院，staff scientist

2011-2012

HHMI/宾夕法尼亚大学医学院，助理研究员

2012-至今

中国科学技术大学，生科院，教授


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　目前研究方向

　　现任中国科学技术大学生命科学院、合肥微尺度物质科学国家研究中心教授。主要从事表观遗传调控、神经退行性疾病、能量代谢调控等方面的神经、分子、细胞和遗传学机制研究。近年来取得了一系列重要研究成果，发表于Cell, Neuron, Nature Communications, PLoS Biology, PNAS, ACS Nano等国际高水平杂志，文章被引用2000余次。


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　代表性论文

1.

Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L and Liu Q. Activity dependent LoNA Regulates Translation by Coordinating rRNA Transcription and Methylation. Nat Commun. 9（1）：1726，2018.

2.

You L, Wang J, Liu T, Zhang Y, Han X, Wang T, Guo S, Dong T, Xu J, Anderson GJ, Liu Q, Chang YZ, Lou X, Nie G Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice. ACS Nano. doi: 10.1021/acsnano.7b08172, 2018.

3.

Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biology. 9(1): e1000575, 2011.

4.

Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1. Neuron 56:66-78, 2007.

5.

Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP Determines mRNA Length and Regulates Isoform Expression. Cell. 150: 53-64, 2012.

6.

Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A, 104:10613-10618, 2007.

7.

Liu Q, Zhang J, Trotter J, Cheng C, Han X, Weeber EJ, Bao J, Herz J, Bu G. Lipoprotein receptor LRP1 regulates age-dependent synaptic and neuronal degeneration by modulating brain lipid metabolism. J. Neurosci. 30:17068-17078. 2010.

8.

Liu Q, Zhang J, Zhu H, Qin C, Chen Q, Zhao B. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB J 21:61-73, 2007.

9.

Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener. 4:17, 2009.

10.

Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem. 284:34045-34053, 2009.

11.

Zhang J, Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein Cell. 6(4):254-64，2015.

12.

Liu Q, Zhao B. Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol. 141:746-754, 2004.

13.

Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G. Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-{beta} Uptake. J.Neurosci. 31: 1644-1651, 2011.

14.

Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene. 29:539-549, 2010.

15.

Zhang J, Liu Q, Chen Q, Liu NQ, Li FL, Lu ZB, Qin C, Zhu H, Huang YY, He W, Zhao BL. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J 20:1212-1214, 2006.


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