刘 强


/uploads/image/2019/03/19/b6d2683caf109a62c2bbc20cb9342973.jpg 姓  名: 刘 强
 地  址: 安徽省合肥市黄山路443号
 邮  编:230027
 电  话:0551-63601179
 电  邮:Liuq2012@ustc.edu.cn




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 教育与科研经历
  1996–2000山东大学,学士, 生物化学与分子生物学专业
  2000-2005

中科院生物物理所,博士,生物物理学

  2005-2010华盛顿大学医学院,博后
  2010-2011华盛顿大学医学院,staff scientist
  2011-2012HHMI/宾夕法尼亚大学医学院,助理研究员
  2012-至今中国科学技术大学,生科院,教授


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 目前研究方向

  现任中国科学技术大学生命科学院、合肥微尺度物质科学国家研究中心教授。获中组部“青年千人计划”,基金委“优秀青年科学基金”,科技部创新人才推进计划“重点领域创新团队”核心成员,动物进化与遗传前沿交叉卓越创新中心骨干,中科院衰老先导科技专项骨干,美国“Hope Center Award”, 国际脑研究组织(IBRO)Neuroscience Fellowship等奖励。主要从事表观遗传调控、神经退行性疾病、能量代谢调控等方面的神经、分子、细胞和遗传学机制研究。近年来取得了一系列重要研究成果,发表于Cell, Neuron, Nature Communications, PLoS Biology, PNAS, ACS Nano等国际高水平杂志,文章被引用2000余次。


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 代表性论文
  1.Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L and Liu Q. Activity dependent LoNA Regulates Translation by Coordinating rRNA Transcription and Methylation. Nat Commun. 9(1):1726,2018.
  2.You L, Wang J, Liu T, Zhang Y, Han X, Wang T, Guo S, Dong T, Xu J, Anderson GJ, Liu Q, Chang YZ, Lou X, Nie G Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice. ACS Nano. doi: 10.1021/acsnano.7b08172, 2018.
  3.Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biology. 9(1): e1000575, 2011.
  4.Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1. Neuron 56:66-78, 2007.
  5.Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP Determines mRNA Length and Regulates Isoform Expression. Cell. 150: 53-64, 2012.
  6.Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A, 104:10613-10618, 2007.
  7.Liu Q, Zhang J, Trotter J, Cheng C, Han X, Weeber EJ, Bao J, Herz J, Bu G. Lipoprotein receptor LRP1 regulates age-dependent synaptic and neuronal degeneration by modulating brain lipid metabolism. J. Neurosci. 30:17068-17078. 2010.
  8.Liu Q, Zhang J, Zhu H, Qin C, Chen Q, Zhao B. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB J 21:61-73, 2007.
  9.Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener. 4:17, 2009.
  10.Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem. 284:34045-34053, 2009.
  11.Zhang J, Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein Cell. 6(4):254-64,2015.
  12.Liu Q, Zhao B. Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol. 141:746-754, 2004.
  13.Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G. Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-{beta} Uptake. J.Neurosci. 31: 1644-1651, 2011.
  14.Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene. 29:539-549, 2010.
  15.Zhang J, Liu Q, Chen Q, Liu NQ, Li FL, Lu ZB, Qin C, Zhu H, Huang YY, He W, Zhao BL. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J 20:1212-1214, 2006.


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