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光寿红


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姓　　名:

光寿红

地　　址:

安徽省合肥市中国科学技术大学生命科学学院

邮　　编:

230027

电　　话:

+86-551-63607812

电　　邮:

sguang(AT)ustc.edu.cn

主　　页:

http://staff.ustc.edu.cn/~sguang/



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　教育与科研经历

2010 -

中国科学技术大学生命科学院，教授

2005 - 2010

美国威斯康星大学遗传系，博士后

1999 - 2004

美国威斯康星大学遗传系，博士生

1996 - 1999

中国科学技术大学生物系，硕士研究生

1991 - 1996

中国科学技术大学生物系，本科


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　目前研究方向

1.

真核细胞中RNA的表达与加工的调节

2.

真核生物中转录调节机制

3.

非编码RNA的表达与调节机制

4.

模式生物的遗传与发育

5.

基因编辑和染色体操纵的新技术和新方法


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　代表性论文

1.

Xiaoyang Wang(#), Chenming Zeng(#), Shanhui Liao(#), Zhongliang Zhu, Jiahai Zhang, Xiaoming Tu, Xuebiao Yao, Xuezhu Feng(*), Shouhong Guang(*), and Chao Xu(*) (2021) Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nature Communications, 2021 Sep 22;12(1):5595. doi: 10.1038/s41467-021-25896-7

2.

Shimiao Liao(#), Xiangyang Chen(#), Ting Xu(#), Qile Jin, Zongxiu Xu, Demin Xu, Xufei Zhou, Chengming Zhu(*), Shouhong Guang(*) and Xuezhu Feng(*) (2021a) Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans Nucleic Acids Research 2021 Sep 20;49(16):9194-9210. doi: 10.1093/nar/gkab662

3.

Zheng Xu(#), Jie Zhao, Minjie Hong, Chenming Zeng, Shouhong Guang(*), Yunyu Shi(*) (2021b) Structural recognition of the mRNA 3’ UTR by PUF-8 restricts the lifespan of C. elegans. Nucleic Acids Research, 2021 Sep 27;49(17):10082-10097. doi: 10.1093/nar/gkab754

4.

Xinya Huang(#), Peng Cheng(#), Chenchun Weng, Zongxiu Xu, Chenming Zeng, Xiangyang Chen(*), Chengming Zhu(*), Shouhong Guang(*), and Xuezhu Feng(*) (2021) A chromodomain protein mediates heterochromatin-directed piRNA expression. PNAS, 2021 Jul 6;118(27):e2103723118. doi: 10.1073/pnas.2103723118

5.

Chenming Zeng (#), Chenchun Weng (#), Xiaoyang Wang (#), Yong-Hong Yan (#), Wen-Jun Li, Demin Xu, Minjie Hong, Shanhui Liao, Meng-Qiu Dong, Xuezhu Feng (*), Chao Xu (*), and Shouhong Guang (*) (2019) Functional proteomics identifies a PICS complex required for piRNA maturation and chromosome segregation. Cell Reports Volume 27, ISSUE 12, P3561-3572.e3, June 18, 2019, DOI: https://doi.org/10.1016/j.celrep.2019.05.076

6.

Chenchun Weng (#), Joanna Kosalka (#), Ahmet C. Berkyurek (#), Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang (*), and Eric A. Miska (*) (2018) The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans. Genes & Development Jan 1;33(1-2):90-102. doi: 10.1101/gad.319293.118.

7.

Chengming Zhu (#), Qi Yan (#), Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng (*) , Shouhong Guang (*) (2018) Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. PNAS 2018 Oct 2;115(40):10082-10087. doi: 10.1073/pnas.1800974115.

8.

Fei Xu (#), Xuezhu Feng (#), Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, and Shouhong Guang (*)（2018）A cytoplasmic Argonaute protein promotes the inheritance of RNAi. Cell Reports. 2018 May 22;23(8):2482-2494.

9.

Xufei Zhou (#), Xuezhu Feng (#), Hui Mao, Mu Li, Fei Xu, Kai Hu, and Shouhong Guang(*)  (2017) RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway. Nature Structural & Molecular Biology 2017 Mar;24(3):258-269. doi: 10.1038/nsmb.3376.

10.

Hui Mao (#), Chengming Zhu (#), Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng (*), and Shouhong Guang (*) (2015) The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans. Current Biology 2015 Sep 21;25(18):2398-403.

11.

Chen X (#), Li M (#), Feng X (*), Shouhong Guang (*) (2015) Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans. Genetics 2015 Dec;201(4):1295-306 doi: 10.1534/genetics.115.181883.

12.

Zhou X (#), Xu F (#), Mao H, Ji J, Yin M, Feng X (*), and Shouhong Guang (*) (2014) Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans. Genetics 2014 May;197(1):121-32.

13.

Xiangyang Chen (#), Fei Xu (#), Chengming Zhu, Jiaojiao Ji, Xufei Zhou, Xuezhu Feng (*), and Shouhong Guang (*) (2014) Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Scientific Reports 2014 Dec. 22;4:7581.

14.

Guang, S., Bochner, A.F., Pavelec, D.M., Burkhart, K.B., Burton, N., and Kennedy, S., (2010) Small regulatory RNAs inhibit RNA Polymerase II during the elongation phase of transcription. Nature, 2010，Jun 24;465(7301):1097-101. doi: 10.1038/nature09095. Epub 2010 Jun 13.

15.

Guang, S. (#), Bochner, A.F. (#), Pavelec, D.M., Burkhart, K.B., Harding, S., Lachowiec, J., and Kennedy, S., (2008) An Argonaute transports siRNAs from the cytoplasm to the nucleus. Science Jul 25;321(5888):537-41. doi: 10.1126/science.1157647. Erratum in: Science. 2009 Dec.


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