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蔡　刚


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Name:

CAI Gang （蔡刚）

Address:

No. 443 Huangshan Rd, Hefei, Anhui, China, 230027

School of Life Science, University of Science & Technology of China

Tel:

86-551-63603802

E-mail:

gcai@ustc.edu.cn



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　EDUCATION AND RESEARCH EXPERIENCE

2010.11-present

Professor, University of Science and Technology

2006.03-2010.11

Research Associate, the Scripps Research Institute, USA

2001.09-2006.03

Ph.D. Shanghai Institutes for Biological Sciences

1997.09-2001.07

B.S. Anhui University B.S. in Microbiology, 2001


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　RESEARCH INTERESTS

I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of chromatin structure and genomic stability, aiming at a structural understanding of the molecular mechanism and designing novel pharmaceuticals for cancer therapy.


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　REPRESENTATIVE PUBLICATIONS

1.

Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*. (2017) 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science, 358, 1206-1209.

2.

Xin, J#., Xu, Z#.,Wang, X#., Tian Y., Zhang, Z. and Cai, G*.（2019） Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Research 29: 655–665. (Cover story)

3.

Qiu, S#., Liu, S#., Zaoti, Z., Wang, X*, Cai, G*. (2019）Modulation of Fatty Acid Synthase by ATR checkpoint kinase Rad3. Journal of Molecular Cell Biology 11: 1098-1100.

4.

Zhang, X., Wang, X*., Zhang, Z., and Cai, G*. (2019) Structure and Functional Interactions of INO80 Actin/Arp Module. J Mol Cell Biol. 11: 345-355. (cover story)

5.

Wang, X*., Ahmad, S., Zhang, Z., Côté, J., Cai, G*. (2018) Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications, 9, 1147.

6.

Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*. (2018) Architecture of SWI/SNF chromatin remodeling complex. Protein Cell, 9, 1045-1049.

7.

Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. (2016) Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655.

8.

Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G.* (2014) Redefining the Modular Organization of the Core Mediator Complex. Cell Research 24, 796-808. (cover story)

9.

Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G.* (2013) Structural flexibility and functional interaction of mediator Cdk8 module, Protein & Cell, 12.4, 4(12): 911~920 (cover story)


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