蔡 刚


/uploads/image/2019/03/07/8601fc24a92e7b4db5953c3541a07d89.png Name: 

CAI Gang (蔡刚)

 Address: 

No. 443 Huangshan Rd, Hefei, Anhui, China, 230027


School of Life Science, University of Science & Technology of China
 Tel:

86-551-63603802

 E-mail:gcai@ustc.edu.cn




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 EDUCATION AND RESEARCH EXPERIENCE
  2010.11-presentProfessor, University of Science and Technology
  2006.03-2010.11

Research Associate, the Scripps Research Institute, USA

  2001.09-2006.03Ph.D. Shanghai Institutes for Biological Sciences
  1997.09-2001.07B.S. Anhui University B.S. in Microbiology, 2001


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 RESEARCH INTERESTS

I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of chromatin structure and genomic stability, aiming at a structural understanding of the molecular mechanism and designing novel pharmaceuticals for cancer therapy.


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 REPRESENTATIVE PUBLICATIONS
  1.Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*. (2017) 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science, 358, 1206-1209.
  2.Wang, X*., Ahmad, S., Zhang, Z., Côté, J., Cai, G*. (2018) Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications, 9, 1147
  3.Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*. (2018) Architecture of SWI/SNF chromatin remodeling complex. Protein Cell, 9, 1045-1049.
  4.

Zhang, X., Wang, X*., Zhang, Z., and Cai, G*. (2019) Structure and Functional Interactions of INO80 Actin/Arp Module. J Mol Cell Biol. (doi: 10.1093/jmcb/mjy062)

  5.Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. (2016) Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655,
  6.Ma, R., Qiu, S., Jiang, Q., Sun, H., Xue, H., Cai, G.,* and Sun, B.* (2017) AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus, International Journal of Medical Microbiology, 06, 307(4–5): 257~267
  7.Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G.* (2014) Redefining the Modular Organization of the Core Mediator Complex. Cell Research 24, 796-808 (Cover story)
  8.Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G.* (2013) Structural flexibility and functional interaction of mediator Cdk8 module, Protein & Cell,12.4, 4(12): 911~920


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