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田志刚


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Name:

Zhigang Tian（田志刚）

Address:

School of Life Sciences , 

University of Science and Technology of China, 230026 Hefei, P. R. China

Tel:

86-551-63600845

Fax:

86-551-63606783

E-mail:

tzg@ustc.edu.cn



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　EDUCATION AND RESEARCH EXPERIENCE

03/1978-12/1982

M.D., Shanxi Medical University, China

03/1983-08/1985

M.S., Immunol, Shandong Acad Med Sci, China

03/1986-03/1989

Ph.D., Immunology, Normal Bethune Med Univ, China

04/1989-12/2001

Assist/Asso/Full Professor, Shandong Acad Med Sci

08/1994-06/1996

Visiting Scientist, NCI, NIH, USA

02/1999-08/1999

Visiting Professor, Med College Virginia, Richmond

08/2000-12/2000

Visiting Scientist, NCI, NIH, USA

01/2001-present

Professor, Univ Sci Tech China, China

01/2002-04/2002

Visiting Scientist, NIAAA, NIH, USA

05/2002-04/2003

Visiting Professor, Kanazawa Univ Cancer Inst, Japan


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　RESEARCH INTERESTS

1.

NK cell subsets and differentiation

2.

NK cell-based immunotherapy of cancer

3.

Liver immune tolerance and diseases


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　REPRESENTATIVE PUBLICATIONS

1.

Zong L, Peng H , Sun C, Li F, Zheng M, Chen Y, Wei H, Sun R, Tian Z*. Breakdown of adaptiveimmunotolerance induces hepatocellular carcinoma in HBsAg-tg mice. Nat Commun. 2019 Jan; 10(1):221.

2.

Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity. 2019 Feb; 50(2):403-417.

3.

Wang X, Sun R, Hao X, Lian Z, Wei H, Tian Z*. IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3. PNAS 2019; 116:17409-17418.

4.

Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*, Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat Commun. 2018 Nov; 9(1):4854.

5.

Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab. 2018 Aug; 28(2):243-255.

6.

Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018 Jul; 19(7):723-732.

7.

Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G , Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C*, Tian Z*. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018 Mar; 9(1):1241.

8.

Fu B,  Zhou Y，Ni X, Tong X, Xu X,  Dong Z, Sun R, Tian Z*, Wei H*. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec; 47:1100-1113.

9.

Li F, Hao X, Chen Y, Bai L, Gao X, Lian Z, Wei H, Sun R, Tian Z*. Microbiota maintains homeostasis of liver-resident γδT-17 cells in a lipid antigen-CD1d–dependent manner. Nat Commun. 2017 Jan; 7:13839.

10.

Yu X, Lan P, Hou X, Han Q, Lu N, Li T, Jiao C, Zhang J, Zhang C*, Tian Z*. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. J Hepatol. 2017 Apr; 66(4):693-702.

11.

Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z*, Dong Z*. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity. 2016 Aug; 45(2):292-304.

12.

Zeng Z, Li L, Chen YY, Wei HM, Sun R, Tian Z*. Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance. J Exp Med. 2016 May; 213(6):1079-93.

13.

Wu X, Sun R, Chen Y, Zheng X, Bai L, Lian Z, Wei H, Tian Z*. Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteria. Hepatology. 2015 Jul; 62(1):253-64.

14.

Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jun; 62(6):1311-8.

15.

Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan; 160(1-2):62-73.


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