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田志刚


/uploads/image/2019/03/19/423d860e94227b28c9361d5581ea06c3.png Name: Zhigang Tian(田志刚)
 Born: Oct, 1956, Shandong, P. R. China
 Address:School of Life Sciences , University of Science and Technology of China, 230026 Hefei, P. R. China
 Tel:86-551-63600845
 Fax:86-551-63606783
 E-mail:tzg@ustc.edu.cn




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 EDUCATION AND RESEARCH EXPERIENCE
  03/1978-12/1982M.D., Shanxi Medical University, China
  03/1983-08/1985

M.S.,Immunol,Shandong Acad Med Sci, China

  03/1986-03/1989Ph.D., Immunology, Normal Bethune Med Univ, China.
  04/1989-12/2001Assist/Asso/Full Professor, Shandong Acad Med Sci
  08/1994-06/1996Visiting Scientist, NCI, NIH, USA
  02/1999-08/1999Visiting Professor, Med College Virginia, Richmond
  08/2000-12/2000Visiting Scientist, NCI, NIH, USA
  01/2001-presentProfessor, Univ Sci Tech China, China
  01/2002-04/2002Visiting Scientist, NIAAA, NIH, USA
  05/2002-04/2003Visiting Professor, Kanazawa Univ Cancer Inst, Japan


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 RESEARCH INTERESTS
  1.NK cell subsets and differentiation
  2.NK cell-based immunotherapy of cancer
  3.Liver immune tolerance and diseases


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 RESEARCH INTERESTS

Currently, we are supported through 5 research projects by National Natural Science Foundation of China, Department of Science & Technology of Chinese Government, and Chinese Academy of Sciences.


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 REPRESENTATIVE PUBLICATIONS
  1.Zong L, Peng H , Sun C, Li F, Zheng M, Chen Y, Wei H, Sun R, Tian Z*. Breakdown of adaptiveimmunotolerance induces hepatocellular  carcinoma in HBsAg-tg mice. Nat Commun. 2019 Jan; 10(1):221.
  2.Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity. 2019 Feb; 50(2):403-417.
  3.Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*, Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat Commun. 2018 Nov; 9(1):4854.
  4.Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab. 2018 Aug; 28(2):243-255.
  5.Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018 Jul; 19(7):723-732.
  6.Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G ,Song J,Wang J, Wei H, Zhang J,Sun R, Zhang C*,Tian Z*. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018 Mar; 9(1):1241.
  7.Fu B,  Zhou Y,Ni X, Tong X, Xu X,  Dong Z,4 Sun R, Tian Z*, Wei H*. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec; 47:1100-1113.
  8.Li F, Hao X, Chen Y, Bai L, Gao X, Lian Z, Wei H, Sun R, Tian Z*. Microbiota maintains homeostasis of liver-resident γδT-17 cells in a lipid antigen-CD1d–dependent manner. Nat Commun. 2017 Jan; 7:13839.
  9.Yu X, Lan P, Hou X, Han Q, Lu N, Li T, Jiao C, Zhang J, Zhang C*, Tian Z*. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. J Hepatol. 2017 Apr; 66(4):693-702.
  10.Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z*, Dong Z*. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity. 2016 Aug; 45(2):292-304.
  11.Zeng Z, Li L, Chen YY, Wei HM, Sun R, Tian Z*. Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance. J Exp Med. 2016 May; 213(6):1079-93.
  12.Wu X, Sun R, Chen Y, Zheng X, Bai L, Lian Z, Wei H, Tian Z*. Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteria. Hepatology. 2015 Jul; 62(1):253-64.
  13.Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jun; 62(6):1311-8.
  14.Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan; 160(1-2):62-73.


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