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魏海明


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Name:

Haiming Wei（魏海明）

Address:

School of Life Sciences,

University of Science and Technology of China, 230026 Hefei, P. R. China

Tel:

86-551-63607379

Fax:

86-551-63606783

E-mail:

ustcwhm@ustc.edu.cn



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　EDUCATION AND RESEARCH EXPERIENCE

1993.08-1996.07

M.s., Immunology, Shandong Academy of Medical Sciences

2000.08-2003.07

Ph. D., Immunology, Shandong University

1996.07-2001.09

Assistant Professor and Associate Professor of Shandong Cancer Biotherapy Center, Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences

2001.09-2005.12

Associate Professor of School of Life Sciences, USTC

2005.12-2014.12

Professor of School of Life Sciences, USTC

2015.01-present

Professor & Vice-Dean of School of Life Sciences, USTC


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　RESEARCH INTERESTS

1.

Innate immunity and immune diseases

2.

Tumor immunity and tumor biotherapy

3.

Recognition and differentiation of NK cells


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　CURRENT RESEARCH PROJECTS

1.

The effect of immunity on gametogenesis and embryonic development, 2018.12-2021.12, supported by National Key Research & Developmental Program of China

2.

NK cells regulation of immune tolerance and immune rejection at the maternal-fetal microenvironment, 2020.1-2024.12, supported by the Natural Science Foundation of China


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　REPRESENTATIVE PUBLICATIONS

1.

Zhou Y, Fu B*, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. PBX1 expression in uterine natural killer cells drives fetal growth. Sci Transl Med. 2020 Apr 1;12(537):eaax1798.

2.

Cong J, Wang X, Zheng X, Wang D , Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metabolism. 2018 Aug 7;28(2):243-255.

3.

Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z*, Wei H*. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol. 2019 Dec; 20(12):1656-1667.

4.

Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural killer cells promote fetal development through the secretion of growth-promoting factors. Immunity. 2017 Dec 19;47(6):1100-1113.

5.

Zheng X, Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z*, Wei H*. EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance. Cancer Res. 2017 Jan 15;77(2):482-493.

6.

Zheng X, Cheng M, Fu B, Fan X, Wang Q, Yu X, Sun R, Tian Z*, Wei H*. Targeting LUNX Inhibits Non-Small Cell Lung Cancer Growth and Metastasis. Cancer Res. 2015 Mar 15;75(6):1080-90.

7.

Lv S, Wang J, Dou S, Yang X, Ni X, Sun R, Tian Z*, Wei H*. Nanoparticles encapsulating HBV-CpG induce therapeutic immunity against hepatitis B virus infection. Hepatology. 2014 Feb 59(2):385-94.

8.

Fu B, Li X, Sun R, Tong X, Ling B, Tian Z*, Wei H*. Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E231-40.

9.

Ni F, Sun R, Fu B, Wang F, Guo C, Tian Z*, Wei H*. IGF-1 promotes the development and cytotoxic activity of human NK cells. Nat Commun. 2013 Feb 12; 4:1479.


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