您当前的位置:首页 > 研究体系 > 分子医学研究部

史庆华


/uploads/image/2019/03/13/f10f566d6884d1c4d28a1907fea3e076.jpg Name: Qinghua Shi(史庆华)
 Born: September 4, 1964, Jiangsu, P. R. China
 Address:Hefei National Laboratory for Physical Science at Microscale and, School of Life Science, 

University of Science and Technology of China, 230026 Hefei, 

CAS Center for Excellence in Molecular Cell Science, P. R. China
 Tel:86-551-3600344/3600442(L)
 Labweb:http://mcg.ustc.edu.cn
 E-mail:qshi@ustc.edu.cn




/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 EDUCATION AND RESEARCH EXPERIENCE
  1985.09-1988.10Graduate for M.S. degree. Kunming Institute of Zoology, Chinese Academy of Sciences.
  1988.11-1992.09

Research Assistant. Anhui Institute of Occupational Health

  1992.10-1993.10Guest Scientist. GSF-National Research Center for Environment and Health, Germany.
  1994.09-1998.06Graduate for Ph.D. degree. GSF-National Research Center for Environment and Health, Germany and, Nanjing Normal University.
  1998.11-2001.12Postdoctoral fellow. Department of Medical Genetics, University of Calgary, Canada.
  2002.01-2004.12Research Fellow. Institute of Chemistry and Cell Biology, Department of Cell Biology, Harvard Medical School.
  2004.12-2018.12Principal Investigator and Professor. Hefei National Laboratory for Physical Science at Microscale and, School of Life Science, University of Science and Technology of China
  2018.12-presentPrincipal Investigator and Professor. Hefei National Laboratory for Physical Science at Microscale and, The First Affiliated Hospital, School of Life Science, University of Science and Technology of China


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 RESEARCH INTERESTS
  1.Cellular and molecular regulation of mammalian meiosis.
  2.Origins and mechanisms of mitotic and meiotic aneuploidy.
  3.Molecular bases and mechanisms of human infertility.


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 CURRENT RESEARCH PROJECTS
  1.Molecular regulation of human/mammalian meiosis.
  2.Molecular mechanisms of oocyte and follicle development.
  3.Identification of genetic mutations causing human spermatogenesis and oogenesis failure.
  4.Origins and mechanisms of mitotic and meiotic aneuploidy.


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 REPRESENTATIVE PUBLICATIONS
  1.Yin H, Ma H, Hussain S, Zhang H, Xie X, Jiang L, Jiang X, Iqbal F, Bukhari I, Jiang H, Ali A, Zhong L, Li T, Fan S, Zhang B, Gao J, Li Y, Nazish J, Khan T, Khan M, Zubair M, Hao Q, Fang H, Huang J, Huleihel M, Sha J, Pandita TK, Zhang Y *, Shi Q (史庆华) *, A homozygous FANCM frameshift pathogenic variant causes male infertility. Genet Med, 21(1):62-70, 2019.
  2.Jiang H, Gao Q, Zheng W, Yin S, Wang L, Zhong L, Ali A, Khan T, Hao Q, Fang H, Sun X, Xu P, Pandita TK, Jiang X*, Shi Q (史庆华) *, MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice. PLoS Genet, 14(5):e1007300, 2018.
  3.Jiang L, Li T, Zhang X, Zhang B, Yu C, Li Y, Fan S, Jiang X, Khan T, Hao Q, Xu P, Nadano D, Huleihel M, Lunenfeld E, Wang PJ, Zhang Y *, Shi Q (史庆华) *, RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Curr Biol, 27(10):1498-1505 e1496, 2017.
  4.Yin S, Jiang X, Jiang H, Gao Q, Wang F, Fan S, Khan T, Jabeen N, Khan M, Ali A, Xu P, Pandita TK, Fan HY, Zhang Y, Shi Q (史庆华) *, Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels. Development, 144(12):2165-2174, 2017.
  5.Zhang Y, Zang Q, Zhang H, Ban R, Yang Y, Iqbal F, Li A *, Shi Q (史庆华) *, DeAnnIso: a tool for online detection and annotation of isomiRs from small RNA sequencing data. Nucleic Acids Res, 44(W1):W166-175, 2016.
  6.Zhang Y, Yu Z, Ban R, Zhang H, Iqbal F, Zhao A, Li A *, Shi Q (史庆华) *, DeAnnCNV: a tool for online detection and annotation of copy number variations from whole-exome sequencing data. Nucleic Acids Res, 43(W1):W289-294, 2015.
  7.Zhang Y, Zhong L, Xu B, Yang Y, Ban R, Zhu J, Cooke HJ, Hao Q, Shi Q (史庆华) *, SpermatogenesisOnline 1.0: a resource for spermatogenesis based on manual literature curation and genome-wide data mining. Nucleic Acids Res, 41(Database issue):D1055-1062, 2013.
  8.Huang Y, Jiang L, Yi Q, Lv L, Wang Z, Zhao X, Zhong L, Jiang H, Rasool S, Hao Q, Guo Z, Cooke HJ, Fenech M, Shi Q (史庆华) *, Lagging chromosomes entrapped in micronuclei are not 'lost' by cells. Cell Res, 22(5):932-935, 2012.
  9.Shi Q (史庆华), King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature, 437(7061):1038-1042, 2005.


相关文章