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张华凤


/uploads/image/2019/06/27/c693aa99ad4caf6b6dbdab8be4be54ec.png Name: Huafeng Zhang (张华凤)
 Address:School of Life Science, The University of Science and Technology of China,

230026, Hefei, P.R. China
 Tel:86-551-63607131(Lab)
 E-mail:hzhang22@ustc.edu.cn




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 EDUCATION AND RESEARCH EXPERIENCE
  09/1992-07/1997B S., Department of Pharmacy, Shenyang Pharmaceutical University
  09/1997-12/1999

M.S., Department of Pharmacology, Shenyang Pharmaceutical University

  05/2000-09/2000Visiting Researcher, University of Tokyo, Japan.
  10/2000-03/2004Ph.D., University of Tokyo, Japan
  04/2004-08/2005Postdoc, Center for Cancer Research, NCI-Frederick, NIH
  09/2005-01/2008Postdoc, Johns Hopkins University School of Medicine
  02/2008-11/2010Research Associate, Johns Hopkins University School of Medicine
  02/2011-presentProfessor, University of Science and Technology of China


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 RESEARCH INTERESTS

The major research interest of Dr. Huafeng Zhang is to decipher molecular basis underlying hypoxia and HIF (Hypoxic-inducible-factor) -mediated tumor development and metastasis, with a goal to harness cancers by targeting HIF-mediated pathways. Apart from mechanistic studies, screening for HIF1-specific inhibitors for cancer therapy is also under way in her lab.


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 REPRESENTATIVE PUBLICATIONS
  1.Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin S, Dang CV, Song L*, Gao P*, Zhang H*. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition stress. Cell Research. 2016; 26(10): 1112-1130.
  2.Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H*. HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports 2014 Sep 25;8(6):1930-42.
  3.Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Wang Y, Gao P*, Tang H*, Zhang H* cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation Conditions. Cell Research 2015 Apr;25(4):429-44
  4.Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P*, Zhang H*. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications. 2014 Oct 10;5:5212.
  5.Yuan Y, Wang L, Du W, Ding Z, Zhang J, Han T, An L, Zhang H*, Liang G*. Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9700-4
  6.Li Z, Zhang H*. Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression. Cell Mol Life Sci. 2015 Oct 23. [Epub ahead of print] PMID:26499846
  7.Huang D, Li C, Zhang H*. Hypoxia and cancer cell metabolism. Acta Biochim Biophys Sin. 2014 Mar;46(3):214-9.
  8.Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL*. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31(14), pp1557-70, 2012.
  9.Yoshida T#, Zhang H# Shen J, Semenza GL, Campochiaro P. Digoxin Inhibits Retinal Ischemia-induced HIF-1a Expression and Ocular Neovascularization FASEB J. 24(6):1759-67,2010 (#Equal Contributors)
  10.Zhang H, Qian DZ, Tan Y, Lee K,Gao P, Ren YR,Rey S, Hammers H, Chang D,1 Pili R, Dang CV, Liu JO and Semenza GL. Digoxin and Other Cardiac Glycosides Inhibit HIF-1a Synthesis and Block Tumor Growth. PNAS 105(50):19579-86,2008
  11.Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem. 283(16):10892-903,2008
  12.Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Dang CV., Semenza GL. HIF-1 represses mitochondrial mass and respiration in VHL-null renal cell carcinoma. Cancer Cell 11(5):407-20,2007
  13.Fukuda R, Zhang H., Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells. Cell. 129(1):111-22,2007


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