您当前的位置:首页 > 研究体系 > 分子医学研究部

瞿 昆


瞿 昆.png

姓  名:

瞿 昆

地  址:

安徽省合肥市蜀山区黄山路443号,

中国科学技术大学生命科学学院

电  话:

86-551-63606257

电  邮:

qukun@ustc.edu.cn




/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 教育与科研经历

1999-2004

中国科学技术大学化学物理系,获学士学位

2004-2010

美国印第安纳大学化学系,获物理化学博士学位

2009-2010

美国希望之城,贝克曼癌症研究中心,生物信息学专家

2010-2016

美国斯坦福大学医学院,生物信息高级研究员,中心主任

2016年至今

中国科学技术大学生命科学学院,教授,博士生导师


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 研究兴趣

1.

精准医学与个性化肿瘤调节

2.

生物信息学、计算生物学与生命科学大数据云计算软件的开发

3.

转录因子、lncRNA与基因调控的表观遗传修饰


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 目前研究项目

1.

T细胞淋巴瘤的表观遗传调控(2018-2021年)

2.

包硅镍钴合金纳米颗粒通过核磁共振成像及抑制炎症小体激活实现肿瘤诊疗一体(2019-2023年)

3.

2019年度“科大新医学”联合基金重要方向项目(2020-2023年)


/uploads/image/2019/01/08/cfe1cd36d60b7f1c06e6497144a0d8cc.jpg

 代表性论文

1.

H. Xie*, W. Zhang*, M. Zhang*, T. Akhtar, Y. Li, W. Yi, X. Sun, Z. Zuo, M. Wei, X. Fang, Z. Yao, K. Dong, S. Zhong, Q. Liu, Y. Shen, Q. Wu, X. Wang, H. Zhao, J. Bao, K. Qu#, T. Xue# “Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids”. Science Advances (2020).

2.

P. Cai*, Auke BC Otten*, B. Cheng, Mitsuhiro A. Ishii, W. Zhang, B. Huang, K. Qu#, Bryan K. Sun# “A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis”. Genome Research (2020).

3.

Fang J, Ma Q, Chu C, Huang B, Li L, Cai P, Batista PJ, Tolentino KEM, Xu J, Li R, Du P, Qu K, Chang HY: Functional classification of chromatin associated lncRNAs via histone modification specific PIRCh-seq analysis. Genome Biology (2019).

4.

Z. Zuo, Y. Jin, W. Zhang, Y. Lu, B. Li & K. Qu “ATAC-pipe: general analysis of genome-wide chromatin accessibility”, Briefings in Bioinformatics, bby056–bby056, 2018.

5.

X. Bao, Z. Siprashvili, B. Zarnegar, R. Shenoy, E. Rios, N. Nady, K. Qu, A. Mah, D. Webster, A. Rubin, G. Wozniak, S. Tao, J. Wysocka, P. Khavari “CSNK1a1 regulates PRMT1 to maintain the progenitor state in self-renewing somatic tissue”, Developmental Cell, 47, 227–239, 2017.

6.

W. Pan, S. Zhu, K. Qu, K. Meeth, J. Cheng, K. He, H. Ma, Y. Liao, X. Wen, C. Roden, Z. Tobiasova, Z. Wei, J. Zhao, J. Liu, J. Zheng, B. Guo, S. Khan, M. Bosenberg, R. Flavell, J. Lu “The DNA methylcytosine dioxygenase Tet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression”, Immunity, 47, 284–297, 2017.

7.

K. Qu*, L. Zaba, A. Satpathy, P. Giresi, R. Li, Y. Jin, R. Armstrong, C. Jin, N. Schmitt, Z. Rahbar, H. Ueno, W. Greenleaf, Y. Kim, H. Chang “Chromatin accessibility landscape of cutaneous T cell lymphoma and dynamic response to HDAC inhibitors”, Cancer Cell, 32, 1-15, 2017.

8.

G. Wu, M. Yuan, S. Shen, X. Ma, J. Fang, L. Zhu, L. Sun, Z. Liu, X. He, D. Huang, T. Li, C. Li, J. Wu, X. Hu, Z. Li, L. Song, K. Qu, H. Zhang & P. Gao “Menin enhances c-Myc-mediated transcription to promote cancer progression” Nature Communications, 8, 15278, 2017.

9.

C. Jin , K. Qu “Application of bioinformatics techniques in revealing the mechanisms of epigenetic regulation“  SCIENTIA SINICA Vitae 47(1), 116-124 , 2017.

10.

K. Qu*, S. Garamszegi*, F. Wu*, et al, J. Mesirov “Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace”, Nature Methods, 13, 245–247, 2016.

11.

K. Qu*, L. Zaba*, P. Giresi, et al, H. Chang “Individuality and dynamics of personal regulomes in human T cells”, Cell Systems, 1:51-61, 2015 (Previewed in Cell System).

12.

Y. Wan*, K. Qu*, Q. Zhang, R. Flynn, O. Manor, Z. Ouyang, J. Zhang, R. Spitale, M. Snyder, E. Segaland H. Chang “Landscape and variation of RNA secondary structure across the human transcriptome” Nature, 505:706-9, 2014 (Highlighted in Nature News & Views).

13.

V. Lopez-Pajares, K. Qu, et al, P. Khavari “A LncRNA-MAF/MAFB Transcription Factor Network Regulates Epidermal Differentiation”, Developmental Cell, 32(6), 693-706, 2015 (Cover Article, Previewed in Developmental Cell).

14.

C. Benitez, K. Qu, et al, S. Kim “An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development”, PLoS Genetics, Oct. 16, 2014.

15.

J. Quinn, I. Ilik, K. Qu, P. Georgiev, et al., H. Chang “Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification”, Nature Biotechnology, 32:933-940, 2014.

16.

P. Batista*, B. Molinie*, J. Wang*, K. Qu, et al., H. Chang “m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells”, Cell Stem Cell, 15(6), 707-719, 2014.

17.

O. Wapinski*, T. Vierbuchen*, K. Qu, et al., H. Chang, and M. Wernig “Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons” Cell, 155(3), 2013.

18.

Y. Wan, K. Qu, Z. Ouyang, and H. Chang“Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing” Nature Protocols, 8(5):849-69, 2013.

19.

N. Rapicavoli, K. Qu, et al., H. Chang “A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics” eLife, July 23, 2013.

20.

X. Bao, J. Tang, V. Lopaz-Pajares, S. Tao, K. Qu, G. Crabtree, P. Khavari “ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4” Cell Stem Cell, 12(2):193-203, 2013.

21.

M. Kretz, D. Webster, C. Chu, Z. Siprashvili, A. Zehnder, K. Qu, et al., H. Chang, and P. Khavari “Control of Somatic Tissue Differentiation by the Long Non-Coding RNA TINCR” Nature, 493(7431):231-5, 2013 (Faculty 1000).

22.

R. Flockhart, D. Webster, K. Qu, et al., P. Khavari “BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration” Genome Research, 22(6):1006-14, 2012 (Highlighted in Nature Reviews Cancer).

23.

Y. Wan, K. Qu, Z. Ouyang, et al., E. Segal, H. Chang. “Genome-wide measurement of RNA folding energies”Molecular Cell, 48:1-13, 2012 (Faculty 1000).

24.

A. Bhaduri, K. Qu, et al., and P. Khavari. “Rapid Identification of Nonhuman Sequencing in High Throughput Sequencing Data Sets” Bioinformatics, 28(8):1174-5, 2012 (Faculty 1000).

25.

N. Gomez-Ospina, A. Chang, K. Qu, A. Oro. “Translocation Affecting Sonic Hedgehog Gene associated with Basal Cell Carcinomas” The New England Journal of Medicine, 366:2233-2234, 2012.

26.

C. Chu, K. Qu, F. Zhong, S. Artandi, H. Chang. “Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions” Molecular Cell, 44(4), 667-678, 2011 (Cover Article, Highlighted in Nature Reviews Genetics and Nature Methods, Faculty 1000).


相关文章