郭 昌


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姓  名:

郭 昌

出生年月:

1987年6月

地  址:

合肥微尺度物质科学国家研究中心

中国科学技术大学

邮  编:

230026

电  话:

15155932590

邮  箱:

guochang@ustc.edu.cn




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 教育与科研经历

2018.03 - 至今

特任教授,博士生导师,合肥微尺度物质科学国家研究中心

2017.02-2018.02

特任研究员,中国科学技术大学,合肥微尺度物质科学国家研究中心

2013.08-2017.01

博士后,德国明斯特大学

2007.09-2013.06

博士,中国科学技术大学

2003.08-2007.06

学士,中国科学技术大学


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 目前研究方向

  研究工作主要集中在不对称合成方向,以新型不对称催化研究为基础,发展惰性化学键的直接手性官能团化反应,建立手性催化模型,提高反应活性与选择性,并将这些方法学用于天然产物的合成,发展高效、原子经济性和环境友好的现代有机合成化学。


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 代表性论文

1.

Chang, X.; Zhang, Q.; Guo, C.* Asymmetric Electrochemical Transformation. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202000016.

2.

Wang, H.; Hu, Q.; Wang, M.; Guo, C.* Enantioselective [4+2] Annulation to the Concise Synthesis of Chiral Dihydrocarbazoles. iScience 2020, 23, 100840.

3.

Zhang, Q.; Chang, X.; Peng, L.; Guo, C.* Asymmetric Lewis Acid Catalyzed Electrochemical Alkylation. Angew. Chem. Int. Ed. 2019, 131, 7073-7077.

4.

Chang, X.; Zhang, Q.; Guo, C.* Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination. Org. Lett. 2019, 21, 4915-4918.

5.

Wang, H.; Guo, C.* Enantioselective γ‐Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine. Angew. Chem. Int. Ed. 2019, 58, 2854-2858.

6.

Chang, X.; Zhang, Q.; Guo. C.* Electrochemical Reductive Smiles Rearrangement for C−N Bond Formation. Org. Lett. 2019, 21, 10-13.

7.

Guo, C.*; Janssen-Müller, D.; Fleige, M.;Lerchen, A.; Daniliuc, C. G.; Glorius, F.* Mechanistic studies on a cooperative NHC organocatalysis/palladium catalysis system: uncovering significant lessons for mixed chiral Pd(NHC)(PR3) catalyst design. J. Am. Chem. Soc. 2017, 139, 4443-4451.

8.

Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F.* Cooperative N-heterocyclic carbene/palladium-catalyzed enantioselective umpolungannulations, J. Am. Chem. Soc. 2016, 138, 7840-7843.

9.

Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F. *Switchable selectivity in an NHC-catalyseddearomatizing annulation reaction, Nat. Chem. 2015, 7, 842-847.

10.

Guo,C.; Sahoo, B.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbenecatalyzed switchable reactions of enals with azoalkenes: formal [4+3] and [4+1] annulations for the synthesis of 1,2-diazepines and pyrazoles, J. Am. Chem. Soc. 2014, 136,17402-17405.

11.

Guo, C.; Schedler, M.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbenecatalyzed formal [3+2] annulation reaction of enals: an efficient enantioselective access to spiro-heterocycles, Angew. Chem. Int. Ed. 2014, 53, 10232-10236.

12.

Guo, C.; Song, J.; Huang, J.-Z.; Chen, P.-H.; Luo, S.-W.; Gong, L.-Z. *Core-structure-oriented asymmetric organocatalyticsubstitution of3-hydroxyoxindoles: application in the enantioselective total synthesis of (+)-folicanthine. Angew. Chem. Int. Ed. 2012, 51, 1046-1050.

13.

Guo, C.; Song, J.; Luo, S.-W.; Gong, L.-Z. *Enantioselective oxidative cross-coupling reaction of 3-indolylmethyl C-H bonds with 1,3-dicarbonyls using a chiral Lewis acid-bonded nucleophile to control stereochemistry. Angew. Chem. Int. Ed. 2010, 49, 5558-5562.

14.

Guo, C.; Xue, M.-X.; Zhu, M.-K.; Gong, L.-Z.* Organocatalytic asymmetric formal [3+2] cycloaddition reaction of iocyanoesters to nitroolefinsleading to highly optically active dihydropyrroles. Angew. Chem. Int. Ed. 2008, 47, 3414-3417.


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