郭 昌
 | 姓 名: | 郭 昌 |
出生年月: | 1987年6月 | |
地 址: | 合肥微尺度物质科学国家研究中心 | |
| 中国科学技术大学 | ||
邮 编: | 230026 | |
电 话: | 15155932590 | |
邮 箱: | guochang@ustc.edu.cn |
| 教育与科研经历 |
2018.03 - 至今 | 特任教授，博士生导师，合肥微尺度物质科学国家研究中心 |
2017.02-2018.02 | 特任研究员，中国科学技术大学，合肥微尺度物质科学国家研究中心 |
2013.08-2017.01 | 博士后，德国明斯特大学 |
2007.09-2013.06 | 博士，中国科学技术大学 |
2003.08-2007.06 | 学士，中国科学技术大学 |
| 目前研究方向 |
| 研究工作主要集中在不对称合成方向，以新型不对称催化研究为基础，发展惰性化学键的直接手性官能团化反应，建立手性催化模型，提高反应活性与选择性，并将这些方法学用于天然产物的合成，发展高效、原子经济性和环境友好的现代有机合成化学。 |
| 代表性论文 |
1. | Chang, X.; Zhang, Q.; Guo, C.* Asymmetric Electrochemical Transformation. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202000016. |
2. | Wang, H.; Hu, Q.; Wang, M.; Guo, C.* Enantioselective [4+2] Annulation to the Concise Synthesis of Chiral Dihydrocarbazoles. iScience 2020, 23, 100840. |
3. | Zhang, Q.; Chang, X.; Peng, L.; Guo, C.* Asymmetric Lewis Acid Catalyzed Electrochemical Alkylation. Angew. Chem. Int. Ed. 2019, 131, 7073-7077. |
4. | Chang, X.; Zhang, Q.; Guo, C.* Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination. Org. Lett. 2019, 21, 4915-4918. |
5. | Wang, H.; Guo, C.* Enantioselective γ‐Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine. Angew. Chem. Int. Ed. 2019, 58, 2854-2858. |
6. | Chang, X.; Zhang, Q.; Guo. C.* Electrochemical Reductive Smiles Rearrangement for C−N Bond Formation. Org. Lett. 2019, 21, 10-13. |
7. | Guo, C.*; Janssen-Müller, D.; Fleige, M.;Lerchen, A.; Daniliuc, C. G.; Glorius, F.* Mechanistic studies on a cooperative NHC organocatalysis/palladium catalysis system: uncovering significant lessons for mixed chiral Pd(NHC)(PR3) catalyst design. J. Am. Chem. Soc. 2017, 139, 4443-4451. |
8. | Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F.* Cooperative N-heterocyclic carbene/palladium-catalyzed enantioselective umpolungannulations, J. Am. Chem. Soc. 2016, 138, 7840-7843. |
9. | Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F. *Switchable selectivity in an NHC-catalyseddearomatizing annulation reaction, Nat. Chem. 2015, 7, 842-847. |
10. | Guo,C.; Sahoo, B.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbenecatalyzed switchable reactions of enals with azoalkenes: formal [4+3] and [4+1] annulations for the synthesis of 1,2-diazepines and pyrazoles, J. Am. Chem. Soc. 2014, 136,17402-17405. |
11. | Guo, C.; Schedler, M.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbenecatalyzed formal [3+2] annulation reaction of enals: an efficient enantioselective access to spiro-heterocycles, Angew. Chem. Int. Ed. 2014, 53, 10232-10236. |
12. | Guo, C.; Song, J.; Huang, J.-Z.; Chen, P.-H.; Luo, S.-W.; Gong, L.-Z. *Core-structure-oriented asymmetric organocatalyticsubstitution of3-hydroxyoxindoles: application in the enantioselective total synthesis of (+)-folicanthine. Angew. Chem. Int. Ed. 2012, 51, 1046-1050. |
13. | Guo, C.; Song, J.; Luo, S.-W.; Gong, L.-Z. *Enantioselective oxidative cross-coupling reaction of 3-indolylmethyl C-H bonds with 1,3-dicarbonyls using a chiral Lewis acid-bonded nucleophile to control stereochemistry. Angew. Chem. Int. Ed. 2010, 49, 5558-5562. |
14. | Guo, C.; Xue, M.-X.; Zhu, M.-K.; Gong, L.-Z.* Organocatalytic asymmetric formal [3+2] cycloaddition reaction of iocyanoesters to nitroolefinsleading to highly optically active dihydropyrroles. Angew. Chem. Int. Ed. 2008, 47, 3414-3417. |
