顾振华


/uploads/image/2019/03/12/b276255ad7576a6f53524928a2e6d4ea.jpg 姓  名: 顾振华
 地  址: 安徽省合肥市包河区金寨路96号中国科学技术大学化学系
 邮  编:230026
 电  话:+86-0551-63600069
 电  邮:zhgu@ustc.edu.cn
 主  页:http://staff.ustc.edu.cn/~zhgu/




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 教育与科研经历
  2012.1-至今中国科学技术大学, 化学系, 教授
  2008.8-2011.12

美国加州大学圣巴巴拉分校, 化学与生物学系, 博士后  导师:A. Zakarian

  2007.8-2008.7

美国加州大学伯克利分校, 化学系, 博士后  导师:P.Vollhardt

  2002.9–2007.6

中科院上海有机化学研究所, 有机化学, 博士  导师: 麻生明

  1998.9–2002.6南京大学, 化学, 学士   导师: 吴美芳


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 目前研究方向

  我们课题组致力于过渡金属催化的有机合成反应和方法学,包括:

  1.

发展新策略高效构建C-C键,C-杂原子;

  2.

发展新的基于过渡金属催化的不对称催化反应,特别是阻旋手性等的高效构建;

  3.新催化剂的设计和开发,实现高化学和立体选择性的转化。


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 代表性论文
  1.Enhanced Reactivity by Torsional Strain of Cyclic Diaryliodonium in Cu-Catalyzed Enantioselective Ring-Opening Reaction, Kun Zhao†, Longhui Duan†, Shibo Xu, Julong Jiang, Yao Fu*, and Zhenhua Gu* (Lead Contact), Chem, 2018, 4, p599–612. This work was highlighted by X-Mol, DOI:10.1016/j.chempr.2018.01.017 (K. Z. and L. D. contributed equally).
  2.Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes, Bin Li, Zengyin Chao, Chunyu Li, Zhenhua Gu*, J. Am. Chem. Soc., 2018, 140 (30), pp 9400–9403. DOI:10.1021/jacs.8b05743.
  3.Enantioselective Synthesis of Biaryl Atropisomers via Pd/Norbornene-Catalyzed Three-Component Cross-Couplings, Linlin Ding, Xianwei Sui, Zhenhua Gu*, ACS Catal., 2018, 8, pp 5630–5635,  DOI:10.1021/acscatal.8b01037
  4.Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes, Bin Li, Zengyin Chao, Chunyu Li, Zhenhua Gu*, J. Am. Chem. Soc., 2018, 140 (30), pp 9400–9403. DOI:10.1021/jacs.8b05743.
  5.Palladium-Catalyzed Enantioselective Synthesis of 2-Aryl Cyclohex-2-enone Atropisomers: Platform Molecules for the Divergent Synthesis of Axially Chiral Biaryl Compounds, Chongqing Pan, Zixi Zhu, Mingkai Zhang, Zhenhua Gu*, Angew. Chem. Int. Ed. 2017, 56, 4777-4781, DOI:10.1002/anie.201701467.
  6.Cleavage of the C(O)–S Bond of Thioesters by Palladium/Norbornene/Copper Cooperative Catalysis: An Efficient Synthesis of 2-(Arylthio)aryl Ketones, Fenggang Sun, Miao Li, Congfa He, Bin Wang, Bin Li, Xianwei Sui, Zhenhua Gu*, J. Am. Chem. Soc., 2016, 138 (24), pp 7456–7459, DOI:10.1002/anie.201509571.
  7.Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy, Jia Feng†, Bin Li†, Yun He, Zhenhua Gu*, Angew. Chem. Int. Ed. 2016, 55, 2186 –2190, DOI:10.1002/anie.201509571 (J. F. and B. L. contributed equally)
  8.Palladium-Catalyzed Catellani ortho-Acylation Reaction: An Efficient and Regiospecific Synthesis of Diaryl Ketones, Yunze Huang, Rui Zhu, Kun Zhao, Zhenhua Gu*, Angew. Chem., Int. Ed. 2015, 54, 12669-12672 DOI:10.1002/anie.201506446.
  9.Palladium-Catalyzed Intramolecular Asymmetric C-H Functionalization/Cyclization Reaction of Metallocenes: An Efficient Approach toward the Synthesis of Planar Chiral Metallocene Compounds, Ruixian Deng,† Yunze Huang,† Xinna Ma, Gencheng Li, Rui Zhu, Bin Wang, Yan-Biao Kang,* and Zhenhua Gu*, J. Am. Chem. Soc. 2014, 136, 4472-4475, DOI: 10.1021/ja500699x. (R. D. and Y. H. contributed equally)
  10.Pd-Catalyzed Chemoselective Catellani Ortho-Arylation of Iodopyrroles: Rapid Total Synthesis of Rhazinal, Xianwei Sui, Rui Zhu, Gencheng Li, Xinna Ma, and Zhenhua Gu*, J. Am. Chem. Soc. 2013, 135, 9318-9321, DOI: 10.1021/ja404494u. This work was highlighted by Synlett 2013, 24, 2023-2031, DOI: 10.1055/s-0033-1339756. (X. S. and R. Z. contributed equally)


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