| 报告题目 | Chemical Biology of Protein Aggregation in the Stressed Proteome |
| 报告人 | 张鑫 教授 |
| 报告人单位 | 美国宾夕法尼亚州立大学化学系和生物化学与分子生物学系 |
| 报告时间 | 2018-08-06 |
| 报告地点 | 合肥微尺度物质科学国家研究中心九楼会议室（9004） |
| 主办单位 | 合肥微尺度物质科学国家研究中心 |
| 报告介绍 | 报告摘要：
We are fosucsed on protein misfolding and aggregation that occur in stressed cells with deficient proteostasis. These molecular events have been associated with a variety of diseases that are termed as protein misfolding diseases. Protein aggregation is a multiple step process that involves misfolded soluble and insoluble aggregates. It is unclear which of these conformations could lead to cytotoxicity that is associated with diseases. In this seminar, I will describe how we have developed chemical methodologies that allow the community to visualize and differentiate, in live cells, the many conformations through the process of protein aggregation.
报告人简介：
张鑫于2001年获得中国科学技术大学学士学位；2001至2004年在中科院大连化物所学习并获得硕士学位；2010年获加州理工学院博士学位，随后进入美国Scripps研究所做博士后研究。张鑫目前任职于美国宾夕法尼亚州立大学化学系和生物化学与分子生物学系。他的多项研究成果发表在Science，PNAS，Cell Reports，JACS和Angew.Chemie等高水平期刊上。张鑫获得的奖项包括2011获“海伦·海·惠特尼”奖（Helen Hay Whitney Fellowship Award）；2012年获“美国化学学会诺贝尔奖得主签名奖”（The American Chemical Society Nobel Laureate Signature Award）；2014获“Burroughs-Wellcome基金成就奖”（The Burroughs-Wellcome Fund Career Award）；2015获“Lloyd and Dottie Huck青年学者奖”（The Lloyd and Dottie Huck Early Career Award）；2018年获美国斯隆研究奖。 |
