| 报告题目 | Au-LSPR Immunoassay biochips |
| 报告人 | Prof. Kuan-Jiuh Lin |
| 报告人单位 | National Chung Hsing University |
| 报告时间 | 2016-10-10 |
| 报告地点 | 中国科学技术大学环资楼939室 |
| 主办单位 | 合肥微尺度物质科学国家实验室、中国科学技术大学化学与材料科学学院 |
| 报告介绍 | 报告摘要：
Plasmonic biochips typically consist of metallic gold or silver nanostructures on substrates through which they exhibit highly sensitive collective electromagnetic oscillations depending on the surrounding dielectric materials. These biochips are known as localized surface plasmon resonance (LSPR) sensors . From a diagnostics perspective, plasmonic-enabled methodologies for routine use and high-throughput detection of disease biomarkers at low concentrations could potentially move from proof-of-principle experiments to point-of-care (POC) clinical evaluation in the near future. Herein, we introduce gold nanoparticle-cluster immunoassay that target molecules are captured via antibody-specific recognition within the hot-spot AU-LSPR biochips. By LSPR coupling of gold nanoparticle-clusters, we demonstrate an effective plasmonic protocol for conducting label-free immunoassays to detect anti-α-synuclein (anti-α-syn), which is believed to be an important pathological biomarker of Parkinson’s disease. For the early detection and screening of this Parkinson’s marker, clinical diagnosis requires a straightforward immunoassay method that can clearly discriminate between anti-α-syn levels on the order of 3.8 ng/mL (0.2 nM; molecular weight 19 KD).
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