| 报告题目 | Transforming Spectroscopy from in vitro to in vivo for Paradigm-shifting Biomedical Applications |
| 报告人 | Prof. CHENG Jixin |
| 报告人单位 | Weldon School of Biomedical Engineering, Department of Chemistry, Purdue Center for Cancer Research, Purdue University |
| 报告时间 | 2014-09-26 |
| 报告地点 | 合肥微尺度物质科学国家实验室九楼会议室 |
| 主办单位 | 合肥微尺度物质科学国家实验室 |
| 报告介绍 | Current medical imaging modalities rely on differences in tissue properties rather than on chemical-content changes deep inside the body. Consequently, a biopsy is routinely needed for ultimate diagnosis of a malignancy. Thus, we need noninvasive imaging technologies that can be used in vivo and can determine in real time the chemical content of deep-tissue. Vibrational spectroscopy has been a powerful tool for quantitative analysis of molecules in gas phase or solutions and has been deployed for label-free analysis of biological tissues. Yet, applying vibrational spectroscopy to non-invasive in vivo imaging is difficult due to limitations in imaging speed and penetration depth. In this presentation, I will present our persistent efforts in transforming molecular spectroscopy from an in vitro analytical tool to a set of in vivo label-free imaging platforms that have been enabling groundbreaking discoveries and paradigm-shifting diagnosis strategies. This transformation is achieved through development of coherent Raman scattering microscopy for real-time spectroscopic imaging of living cells and development of vibration-based photoacoustic endoscopy/tomography for bond-selective imaging of deep tissues. Potentially transformative applications to cancer metabolism, cardiovascular disease and neuroscience will be presented.
Biosketch: Professor Cheng is a world-renowned pioneer in the rising field of label-free spectroscopic imaging field. His laboratory publishes papers in Nature Photonics, Nature Nanotechnology, PNAS, Phys Rev Lett, Angewandte Chemie and other journals. He is authored in over 160 peer-reviewed articles that have been cited more than 10,000 times. He achieved an h-index of 49 (Google Scholar) at the age of 43. His leadership is also demonstrated as the organizer of 23 national/international symposia, over 160 invited talks, and as lead editor of the first book on Coherent Raman Scattering Microscopy, published by CRC Press in 2012. His is a co-inventor of CARS microscope which is now available through Olympus and Leica. In 2013 He founded Vibronix Inc with the mission of saving lives through label-free imaging technology.
Professor Cheng’s achievements have been recently recognized by Fellow of American Institute of Medicine and Biological Engineering (2014), Purdue University Faculty Scholar (2012-17), College of Engineering Early Career Research Award (2011), Research Excellence Award from Purdue Center for Cancer Research (2011), and Outstanding Young Scientist Award from Chinese National Academy of Sciences (2009).
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