| 报告题目 | Nano-enabled technologies - with a special focus on nanowires for life science applications |
| 报告人 | Prof. Lars Montelius |
| 报告人单位 | Division of Solid State Physics, Lund University |
| 报告时间 | 2013-09-01 |
| 报告地点 | 合肥微尺度物质科学国家实验室九楼会议室 |
| 主办单位 | 合肥微尺度物质科学国家实验室 |
| 报告介绍 | 报告摘要：
In recent years we have witnessed how nanotechnology have developed from being a more research oriented technology towards a more mature technology capable to cope with industrial needs. Especially, this has followed as a consequence of an increased worldwide funding being directed towards nano-enabled applications. Our research efforts in Lund at the Nanometer Structure Consortium, being based on fundamental material science understanding, have also a strong application and engineering orientation. A key enabling technology is processing and fabrication of nanostructures and nanostructured surfaces. In this talk I will briefly discuss various techniques for fabrication of nanostructures, primarily emerging technologies such as nanoimprint lithography and nanowire fabrication and combinations thereof. Especially, I will present how epitaxially grown nanowires can be employed for studies of neuronal outgrowth, cellular response and cellular survival [1-4]. Research on neural interfaces [5] may lead to new important possibilities for modern society, such us novel medical treatments and new generation of brain machine interfaces. Neuronal interfaces made of nanostructures are expected to provide new unprecedented possibilities for neural interfaces [6,7]. It has already been shown that such interfaces made of nanostructures may provide better spatial resolution, shorter cell-to-electrode distance and better electrical properties. They may also improve biocompatibility and provide new functionalities [5-7]. Moreover, nanostructures provide an excellent opportunity for understanding and control of biological processes on the subcellular level [8]. In my talk I will present our first in vivo recordings done with nanowire based probes employing arrays of vertical GaP epitaxial nanowires as scaffolds. We believe that the nanowire electrodes have a big potential and may enable in vivo recordings from very small neuronal elements, such as synapses and dendrites. This work was supported by the Swedish Research Council (VR) Linnaeus grant No. 60012701 and VR project No. 621-2009-3266 and The Knut and Alice Wallenberg Foundation project No. KAW 2004.0119. [1] Martensson, et al, Nanowire Arrays Defined by Nanoimprint Lithography, Nano Lett.; 2004; 4(4); 699-702 [2] Waldemar Hällström et al, Gallium Phosphide Nanowires as a Substrate for Cultured Neurons, Nanoletters 7, 2960 (2007) [3] D. B. Suyatin, W. Hällström, L. Samuelson, L. Montelius, C. N. Prinz, M. Kanje: Gallium phosphide nanowire arrays and their possible application in cellular force investigations, J.Vac.Sci.Technol. B, 27 (6), 3092-3094, 2009 [4] W. Hällström, M. Lexholm, D. Suyatin, G. Hammarin, D. Hessman, L. Samuelson, L. Montelius, M. Kanje, C. N. Prinz : Fifteen-picoNewton force detection from neural growth cones using nanowire arrays, Nano Letters, 10, 782-787, 2010. [5] P. Fromherz: Neuroelectronic Interfacing: Semiconductor Chips with Ion Channels, Nerve Cells, and Brain; Nanoelecrtonics and Information Technology; Berlin, 781-810, 2003. [6] N. A. Kotov, J. O. Winter, I. P. Clements, E. Jan, B. P. Timko, S. Campidelli, S. Pathak, A. Mazzatenta, C. M. Lieber, M. Prato, R. V. Bellamkonda, G. A. Silva, N. W. S. Kam, F. Patolsky, L. Ballerini: Nanomaterials for Neural Interfaces, Adv. Mater., 21, 3970–4004, 2009. [7] T. Dvir; B. P. Timko, D. S. Kohane, R. Langer: Nanotechnological strategies for engineering complex tissues, Nat. Nanotechnol., 6 (12), 13-22, 2011. [8] W. Hällström, C. N. Prinz, D. Suyatin, L. Samuelson, L. Montelius, M. Kanje: Rectifying and Sorting of Regenerating Axons by Free-Standing Nanowire Patterns: A Highway for Nerve Fibers, Langmuir, 25 (8), 4343-4346, 2009. |
