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姚东宝


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姓　　名:

姚东宝

地　　址:

安徽省合肥市包河区金寨路96号

邮　　编:

230026

电　　邮:

dbyao@ustc.edu.cn

电　　话:

0551-63600624

主　　页:

https://faculty.ustc.edu.cn/yaodongbao



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　教育与科研经历

2025年4月至今

中国科学技术大学化学与材料科学学院，副教授，博士生导师

2020年8月至2025年3月

中国科学技术大学高分子科学与工程系，特任副研究员

2017年11月至2020年7月

中国科学技术大学高分子科学与工程系，博士后 (合作导师：梁好均 教授)

2016年9月至2017年9月

美国德克萨斯大学奥斯汀分校，博士联培 (导师：Andrew D. Ellington 教授)

2012年9月至2017年11月

中国科学技术大学高分子科学与工程系，理学博士 (导师：梁好均 教授)

2008年9月至2012年6月

济南大学高分子材料与工程系，工学学士


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　目前研究方向

核酸纳米组装结构的设计、构筑及功能应用，主要包括：


1. DNA可编程纳米粒子超晶格组装与功能材料                       


2. 动态可编程DNA反应网络的设计与构建


3. 核酸/多肽自组装反应网络驱动的CRISPR-dCas9基因转录调控


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　代表性论文(#共同第一作者，*通讯作者)

1.

Bárbara B Mendes#, João Conniot#, Aviram Avital#, Dongbao Yao#, Xingya Jiang#, Xiang Zhou#, Noga Sharf-Pauker#, Yuling Xiao#, Omer Adir#, Haojun Liang*, Jinjun Shi*, Avi Schroeder*, João Conde*, Nanodelivery of nucleic acids. Nature Reviews Methods Primers 2022, 2 (1), 24.

2.

Dongbao Yao#,*, Yunhan Zhang#, Xiang Zhou#,*, Xiaoyun Sun, Xiaoyu Liu, Junxiang Zhou, Wei Jiang, Wenqiang Hua*, Haojun Liang*, Catalytic-assembly of programmable atom equivalents. Proceedings of the National Academy of Sciences 2023, 120 (18), e2219034120.

3.

Xiang Zhou#, Dongbao Yao#,*, Wenqiang Hua, Ningdong Huang, Xiaowei Chen, Liangbin Li, Miao He, Yunhan Zhang, Yijun Guo, Shiyan Xiao*, Fenggang Bian*, Haojun Liang*, Programming Colloidal Bonding Using DNA Strand-Displacement Circuitry. Proceedings of the National Academy of Sciences 2020, 117 (11), 5617-5623.

4.

Xiaoyun Sun#, Wenqiang Hua#, Xiaoyu Liu, Jing Jin, Jianing Zhang, Jie Tian, Bin Zheng, Wei Jiang, Dongbao Yao*, Haojun Liang, Programming Supercrystals Using DNA-Functionalized Colloids That Can Replicate Themselves. Angewandte Chemie International Edition 2024, 63 (22), e202403492.

5.

Xiaoyu Liu#, Dongbao Yao#,*, Yun Wang, Dian Ni, Wenqiang Hua,*, Jie Tian, Liulin Yang, Haixin Lin, Haojun Liang, Zhaoxiang Deng*, Implementation of Digital Computing by Colloidal Crystal Engineering with DNA. Journal of the American Chemical Society 2024, 146 (44), 30573-30583.

6.

Miao He#, Xiang Zhou#,*, Zhigang Li, Xue Yin, Wenjie Han, Junxiang Zhou, Xiaoyun Sun, Xiaoyu Liu, Dongbao Yao*, Haojun Liang*, Programmable Transcriptional Modulation with a Structured RNA-Mediated CRISPR-dCas9 Complex. Journal of the American Chemical Society 2022, 144 (28), 12690-12697.

7.

Dongbao Yao#, Tingjie Song#, Xianbao Sun, Shiyan Xiao*, Fujian Huang, Haojun Liang*, Integrating DNA-Strand-Displacement Circuitry with Self-Assembly of Spherical Nucleic Acids. Journal of the American Chemical Society 2015, 137 (44), 14107-14113.

8.

Dongbao Yao, Sanchita Bhadra, Erhu Xiong, Haojun Liang, Andrew D Ellington*, Cheulhee Jung*, Dynamic Programming of a DNA Walker Controlled by Protons. ACS Nano 2020, 14 (4), 4007-4013.

9.

Yijun Guo#, Dongbao Yao#,*, Bin Zheng, Xianbao Sun, Xiang Zhou, Bing Wei, Shiyan Xiao, Miao He, Chengxu Li, Haojun Liang*, pH-Controlled Detachable DNA Circuitry and Its Application in Resettable Self-Assembly of Spherical Nucleic Acids. ACS Nano 2020, 14 (7), 8317-8327.

10.

Xiaoyun Sun#, Dongbao Yao#,*, and Haojun Liang*, pH-Controlled Resettable Modular DNA Strand-Displacement Circuits. Nano Letters 2023, 23 (24), 11540-11547.

11.

Xiaoyu Liu#, Yunhan Zhang#, Wenqiang Hua#, Yun Wang, Dian Ni, Jie Tian, Dongbao Yao*, Zhaoxiang Deng*, Catalytic-Assembly of Nanoparticle Supercrystals by a pH-Controlled DNA Strand-Displacement Circuit. JACS Au 2025, 5(8), 4055-4063.

12.

Xiang Li#, Dongbao Yao#,*, Junxiang Zhou, Xiang Zhou, Xianbao Sun, Bing Wei, Chengxu Li, Bin Zheng, Haojun Liang*, Cascaded DNA Circuits-Programmed Self-Assembly of Spherical Nucleic Acids for High Signal Amplification. Science China Chemistry 2020, 63(1), 92-98.


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