 | 姓 名: | 王嘉倍 |
地 址: | 中国科学技术大学附属第一医院南区3号楼14层 | |
电 话: | 0551-62284121 | |
电 邮: | jbwang16@ustc.edu.cn |
| 工作经历 |
2023.12-至今 | 中国科学技术大学附属第一医院，研究员（二级岗）、主任医师 |
2018.11-2023.11 | 中国科学技术大学附属第一医院，研究员、副主任医师 |
| 教育经历 |
2008.09-2011.07 | 哈尔滨医科大学，医学博士 |
2005.09-2008.07 | 哈尔滨医科大学，医学硕士 |
1999.09-2004.07 | 哈尔滨医科大学，医学学士 |
| 研究方向 |
| 肝胆肿瘤的发病机制、代谢、免疫微环境、靶免治疗及耐药逆转 | |
| 代表性论文 |
1. | Yufeng Liu, Linmao Sun, Hongrui Guo, Shuo Zhou, Chunxu Wang, Changyong Ji, Fanzheng Meng, Shuhang Liang, Bo Zhang, Yubin Yuan, Kun Ma, Xianying Li, Xinyu Guo, Tianming Cui, Ning Zhang, Jiabei Wang, Yao Liu, Lianxin Liu. Targeting SLP2-mediated lipid metabolism reprograming restricts proliferation and metastasis of hepatocellular carcinoma and promotes sensitivity to Lenvatinib. Oncogene. 2023 Jan;42(5):374-388.（通讯作者） |
2. | Liu Y, Xun Z, Ma K, Liang S, Li X, Zhou S, Sun L, Liu Y, Du Y, Guo X, Cui T, Zhou H, Wang J, Yin D, Song R, Zhang S, Cai W, Meng F, Guo H, Zhang B, Yang D, Bao R, Hu Q, Wang J, Ye Y, Liu L. Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy. J Hepatol. 2023 Apr;78(4):770-782. (通讯作者) |
3. | Chenyang Zheng, Bo Zhang, Yunyun Li, Kejia Liu, Wei Wei, Shuhang Liang, Hongrui Guo, Kun Ma, Yao Liu*, Jiabei Wang*, Lianxin Liu*. Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression. Adv Sci (Weinh). 2023 Jun;e2206798.（通讯作者） |
4. | Li H, Liu Y, Cheng C, Wu Y, Liang SH, Wu L, Wang H, Tu CY, Yao HH, Meng FZ, Zhang B, Wang W, Wang JB, Liu LX. UBE2O reduces the effectiveness of interferon-α via degradation of IFIT3 in hepatocellular carcinoma. Cell Death Dis. 2023 Dec 21;14(12):854.（通讯作者） |
5. | Li X, Liang S, Fei M, Ma K, Sun L, Liu Y, Liu L, Wang J. LncRNA CRNDE Drives the Progression of Hepatocellular Carcinoma by inducing the Immunosuppressive Niche. Int J Biol Sci. 2024 Jan 1;20(2):718-732.（通讯作者） |
6. | Fei M, Li X, Liang S, Zhou S, Wu H, Sun L, Liu Y, Hu Q, Liu L, Wang J. LncRNA PWRN1 inhibits the progression of hepatocellular carcinoma by activating PKM2 activity. Cancer Lett. 2024 Mar 1;584:216620.（通讯作者） |
7. | Ma K, Chu J, Liu Y, Sun L, Zhou S, Li X, Ji C, Zhang N, Guo X, Liang S, Cui T, Hu Q, Wang J, Liu Y, Liu L. Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression. Adv Sci (Weinh). 2024 Mar 9:e2400676.（通讯作者） |
8. | Li J, Yang F, Wang Z, Zheng S, Zhang S, Wang C, He B, Wang JB, Wang H. METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer. Cell Prolif. 2024 May;57(5):e13590.（通讯作者） |
9. | Sun L, Liu Y, Guo X, Cui T, Wu C, Tao J, Cheng C, Chu Q, Ji C, Li X, Guo H, Liang S, Zhou H, Zhou S, Ma K, Zhang N, Wang J, Liu Y, Liu L. Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors. Nat Commun. 2024 Jun 18;15(1):5209.（通讯作者） |
10. | Fu Y, Guo X, Sun L, Cui T, Wu C, Wang J, Liu Y, Liu L. Exploring the role of the immune microenvironment in hepatocellular carcinoma: Implications for immunotherapy and drug resistance. Elife. 2024 Aug 15;13:e95009.（通讯作者） |
11. | Fu Y, Guo X, Sun L, Cui T, Wang J, Liu Y, Liu L. Exploring the Interplay of Diet, Obesity, Immune Function, and Cancer. Cancer Discov. 2024 Nov 1;14(11):2047-2050. （通讯作者） |
12. | Zhai F, Pan G, Xue L, Cheng C, Wang J, Liu Y, Liu L. PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression. Cancer Res. 2025 Feb 1;85(3):535-550.（通讯作者） |
13. | Guo X, Cui T, Sun L, Fu Y, Cheng C, Wu C, Zhu Y, Liang S, Liu Y, Zhou S, Li X, Ji C, Ma K, Zhang N, Chu Q, Xing C, Deng S, Wang J, Liu Y, Liu L. A STT3A-dependent PD-L1 glycosylation modification mediated by GMPS drives tumor immune evasion in hepatocellular carcinoma. Cell Death Differ. 2025 May;32(5):944-958.（通讯作者） |
14. | Cheng C, Zha Q, Sun L, Cui T, Guo X, Xing C, Chen Z, Ji C, Liang S, Tao S, Chu J, Wu C, Chu Q, Gu X, Zhang N, Fu Y, Deng S, Zhu Y, Wang J, Liu Y, Liu L. VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment. Signal Transduct Target Ther. 2025 Jan 24;10(1):26.（通讯作者） |
15. | Fanzheng Meng, Hairui Li, Yabin Huang, Chunxu Wang, Yufeng Liu, Chunting Zhang, Danlei Chen, Taofei Zeng, Shenyu Zhang, Yunyun Li, Bo Zhang, Chuandong Lang, Jie Xia, Wanxiang Xiong, Shixiang Pan, Xuedan Sun, Rick F. Thorne, Yao Liu, Jiabei Wang, Shugeng Zhang, Ruipeng Song, Jizhou Wang, Lianxin Liu. Author Correction: RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma. Nat Cancer. 2025 Jul;6(7):1223-1241.（通讯作者） |
16. | Tianming Cui, Linmao Sun, Xinyu Guo, Cheng Cheng, Ning Zhang, Shuo Zhou, Qi Chu, Changjian Xing, Shuhang Liang, Yufeng Liu, Changyong Ji, Xianying Li, Shengwei Tao, Xuetian Gu, Kun Ma, Chenghui Wu, Junhui Chu, Yumin Fu, Sitao Han, Yuchen Zhang, Jiareng Ye, Yao Liu, Jiabei Wang, Lianxin Liu. Tumor-Derived CD109 Orchestrates Reprogramming of Tumor-Associated Macrophages to Dampen Immune Response. J Hepatol. 2025 Oct;83(4):946-958.（通讯作者） |
17. | Shuo Zhou, Yao Liu, Ning Zhang, Linmao Sun, Changyong Ji, Tianming Cui, Qi Chu, Shugeng Zhang, Jiabei Wang, Lianxin Liu. Glycolytic enzyme PFKFB4 governs lipolysis by promoting de novo lipogenesis to drive the progression of hepatocellular carcinoma. Cancer letters. 2025, 626 217774（通讯作者） |
18. | Huang Y, Lu H, Liu Y, Wang J, Xia Q, Shi X, Jin Y, Liang X, Wang W, Ma X, Wang Y, Gong M, Li C, Cang C, Cui Q, Chen C, Shen T, Liu L, Wang X. Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis. EMBO J. 2025 Mar;44(5):1414-1441.（第一作者） |
19. | Xie W, Sun L, Fu Y, Liu Y, Wang J, Liu L. Contrast-enhanced MRI for Hepatocellular Carcinoma Assessment: Advances in Contrast Agents and Immunotherapy. Acad Radiol. 2025 Nov 17:S1076-6332(25)01033-5.（通讯作者） |
20. | Zhang N, Sun L, Zhou S, Ji C, Cui T, Chu Q, Ye J, Liang S, Ma K, Liu Y, Li X, Guo X, Zhang W, Gu X, Cheng C, Zha Q, Tao S, Zhang Y, Chu J, Wu C, Zhang Y, Wang J, Liu Y, Liu L. Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation. Nat Commun. 2025 Apr 3;16(1):3177.（通讯作者） |
