 | Name: | Dou Zhen （窦震） |
| Address: | Room 545, Biology Building, | |
| University of Science and Technology of China, 230027 Hefei, P. R. China | ||
| Tel: | 86-551-63607141 | |
| Fax: | 86-551-63607141 | |
| E-mail: | douzhen@ustc.edu.cn |
| Education and Research Experience |
| 1994.09-1998.07 | Department of Biology, Anhui University Major: Microbiology, Degree: Bachelor of Science |
| 1998.09-2004.11 | School of Life Sciences, USTC Major: Molecular and Cellular Biology, Degree: Ph.D. |
| 2004.12-2007.04 | School of Life Sciences, USTC Post-doctoral researcher |
| 2005.05-2005.12 | Morehouse School of Medicine, USA Visiting scholar |
| 2007.05-2009.10 | Max-Planck Institute of Biochemistry, Germany Post-doctoral researcher |
| 2010.01-present | Hefei National Laboratary for Physical Science at the micro-scale, University of Science and Technology of China, associated professor |
| Honors |
| Scholarship to attend 5th Doctoral students conference of APRU (Association of Pacific Rim Universities) (2004, Sydney) | |
| Postdoctoral researcher fellowship from Max-Planck Society, Germany (2007-2009) | |
| Excellent research paper award of School of Life Sciences, USTC. (2015) |
| Professional Membership |
| Member of the American Society for Cell Biology | |
| Member of the Chinese Society of Cell Biology |
| Research Interests |
| Kinetochore and Mitosis; Mitotic kinases; Ubiquitin-proteasome system in cell cycle control; | |
| Genome instability and cancer. |
| Representative Publications |
| 1. | Dou Z#, Liu X#, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*. 2015. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci U S A. 112(33): E4546-55. |
| 2. | Wang X, Yu H, Xu L, Zhu T, Zheng F, Fu C, Wang Z, Dou Z*. 2014. Dynamic autophosphorylation of Mps1 kinase is required for faithful mitotic progression. PLOS ONE. 9 (9): e0104723. |
| 3. | Zhu T#, Dou Z#, Qin B, Jin C, Wang X, Xu L, Wang Z, Zhu L, Liu F, Gao X, Ke Y, Wang Z, Aikhionbare F, Fu C, Ding X, Yao X*. 2013. Phosphorylation of Microtubule-binding Protein Hec1 by Mitotic Kinase Aurora B Specifies Spindle Checkpoint Kinase Mps1 Signaling at the Kinetochore. J. Biol. Chem. 288: 36149-36159. (# equal contribution) |
| 4. | Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S*, Bolanos-Garcia VM*. 2012. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem J. 448: 321-8. |
| 5. | Dou Z, von Schubert C, Körner R, Santamaria A, Elowe S and Nigg EA*. 2011. Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1. PLoS ONE. 6(4):e18793. |
| 6. | Hua S, Wang Z, Jiang K, Huang Y, Ward T, Zhao L, Dou Z*, Yao X*. 2011. CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment. J Biol Chem. 286: 1627-38. (* corresponding author) |
| 7. | Zhao L, Chu J, Yuan K, Liu J, Yan F, Miao Y, Shaw A, Jin C, Dou Z*, Yao X*. 2010. Dimerization of CPAP orchestrates centrosome cohesion plasticity. J Biol. Chem. 285: 2488-97. (* corresponding author) |
| 8. | Elowe S, Dulla K, Uldschmid A, Li X, Dou Z, Nigg EA. 2010. Uncoupling BubR1 spindle checkpoint and chromosome congression functions. J Cell Sci. 123: 84-94. |
