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The Transition Path Time Distribution - Protein Folding, Quantum Mechanics, Tunneling Times and Uncertainty

来源:合肥微尺度物质科学国家实验室    浏览次数:0


报告题目   The Transition Path Time Distribution - Protein Folding, Quantum Mechanics, Tunneling Times and Uncertainty
报告人   Prof. Eliyahu Pollak
报告人单位   Chairman, Chemical Physics Department, Weizmann Institute of Science, Israel
报告时间   2018-01-29   10:00
报告地点   合肥微尺度物质科学国家研究中心一楼科技展厅
主办单位   合肥微尺度物质科学国家研究中心、 国际化学理论中心、中国科学技术大学化学与材料科学学院
报告介绍 Abstract:
Recent experimental measurements of the transition path time distributions of proteins moving from the folded to the unfolded state and vice versa, presented theory with challenges. Analysis of the results suggested barrier heights that are much lower than the free energies of activation of the observed transitions. Secondly, the theory used was based on a strong friction model, why is such a model at all applicable to the protein folding problem? A different aspect is the question whether one can use the transition path time distribution in a quantum mechanical context, to obtain insight into some of intriguing questions such as tunneling and quantum reflection times.  
In this talk, I introduce the paradigm of a transition path barrier height for the protein folding problem, and show that it should be smaller than the activation energy, resolving the low barrier height puzzle. The transition path distribution for a parabolic barrier is derived for arbitrary memory friction.
In the second phase, the quantum mechanical transition path time probability distribution will be discussed. Highlights include a vanishing mean tunneling time at the parabolic barrier crossover temperature and that increasing the length of the path traversed decreases the mean transition time. The transition path time distribution is used to define a tunneling flight time and show that it vanishes for tunneling through an Eckart and square barrier. A study of quantum reflection reveals the role of coherence of the incident wavepacket on the tunneling times. Finally, using time averaging it becomes possible to predict the momentum and position of a single quantum particle with an uncertainty which is less than ħ/2 and to derive a time energy uncertainty relation.
 
Biosketch:
Chairman, Chemical Physics Department, Weizmann Institute of Science, Rehovot,76100, Israel.
Fellow, American Association for the Advancement of Science.
TUM Ambassador, Technische Universitat Munchen.
Meitner-Humboldt Research Award – continuation.
Visiting Pitzer Professor,University of California,Berkeley.
Meitner-Humboldt Research Award.
       Fellow, American Physical Society.

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