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EDUCATION AND RESEARCH EXPERIENCE
| 3/1978-12/1982 |
M.D., Shanxi Medical University, China |
| 3/1983-8/1985 |
M.S.,Immunol,Shandong Acad Med Sci, China |
| 3/1986-03/1989 |
Ph.D., Immunology, Normal Bethune Med Univ, China. |
| 4/1989-12/2001 |
Assist/Asso/Full Professor, Shandong Acad Med Sci, |
| 8/1994-6/1996 |
Visiting Scientist, NCI, NIH, USA |
| 2/1999–8/1999 |
Visiting Professor, Med College Virginia, Richmond |
| 8/2000–12/2000 |
Visiting Scientist, NCI, NIH, USA |
| 1/2001–present |
Professor, Univ Sci Tech China, China |
| 1/2002–4/2002 |
Visiting Scientist, NIAAA, NIH, USA |
| 5/2002–4/2003 |
Visiting Professor, Kanazawa Univ Cancer Inst, Japan |
RESEARCH INTERESTS
| 1) |
Innate immunity of liver |
| 2) |
Regulatory function of NK cells in specific immune response ; |
| 3) |
Differentiation process of NK cells. |
CURRENT RESEARCH PROJECTS
| We are supported through more than 10 research projects by National Natural Science Foundation of China, Department of Science & Technology of Chinese Government, and Chinese Academy of Sciences through nine research projects. |
REPRESENTATIVE PUBLICATIONS
| 1) |
Jiang W, Sun R, Wei H, Zhou R, Tian Z. Toll-like receptor 9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol 2009, 182 (6:):3768-74 |
| 2) |
Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.. Hepatology 2009, 49:940-9 |
| 3) |
Wei HX, Chuang YH, Li B, Wei H, Sun R, Moritoki Y, Gershwin ME, Lian ZX, Tian Z. CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. J Immunol. 2008;181(10):7221- 9 |
| 4) |
Chen QF, Wei HM, Sun R, Zhang J, Tian Z. Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. Hepatology 2008, 47:648-58 |
| 5) |
Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology. 2007; 46(3):706-15. |
| 6) |
Zhou R, Wei H, Sun R, Tian ZG. NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice. Proceedings of National Academy of Science U S A. 2007; 104(18):7512-5. |
| 7) |
Dong Z, Zhang J, Sun S, Wei H, Tian ZG. Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. Hepatology 2007; 45(6):1400-12. |
| 8) |
Zhou R, Wei H, Sun R, Tian ZG. Recognition of double-stranded RNA by Toll-like receptor 3 induces severe small intestinal injury in mice1. Journal of Immunology. 2007; 178(7):4548-56 |
| 9) |
Zhou RB, Wei HM, Tian ZG. NK3-like NK cells are involved in protective effect of polyinosinic-polycytidylic acid on type I diabetes in nonobese diabetic mice. Journal of Immunology 2007; 178 (4): 2141-2147 |
| 10) |
Chen YY, Sun R, Jiang W, Wei HM, Tian ZG. Liver-specific HBsAg transgenic mice are over-sensitive to Poly (I:C)-induced liver injury in NK cell- and IFN--dependent manners. Journal of Hepatology 2007; 47(2):183-90. |
| 11) |
Li B, Sun R, Wei H, Gao B, Tian ZG. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology. 2006; 43(6):1211-9. |
| 12) |
Zhang R, Zheng X, Li B, Wei H, Tian ZG. Human NK cells positively regulate gammadelta T cells in response to Mycobacterium tuberculosis. Journal of Immunology 2006; 176(4):2610-6. |
| 13) |
Wang J, Sun R, Wei H, Dong Z, Gao B, Tian ZG. Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. Journal of Hepatology 2006; 44(3):446-54. |
| 14) |
Jiang W, Sun R, Wei HM, Tian ZG. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proceedings of National Academy of Sciences USA 2005; 102 (47): 17077-17082. |
| 15) |
Dong Z, Wei H, Sun R, Hu Z, Gao B, Tian ZG. Involvement of natural killer cells in PolyI : C-induced liver injury. Journal of Hepatology 2004; 41 (6): 966-973 |
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